Gene name
Anpep (APN,CD13,PEPN,Lap-1,Lap1)
Experiment(s)
For this entry:
AMPN_HUMAN (Anpep)
| Species | Homo sapiens |
|---|---|
| Localization | Apical plasma membrane |
| Reference |
Wessels HP,Hansen GH,Fuhrer C,Look AT,Sjöström H,Norén O,Spiess M (1990) Aminopeptidase N is directly sorted to the apical domain in MDCK cells., J Cell Biol, 111, 2923-30. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Kidney |
| Cell | MDCK cells (distal tubule) |
| Notes | Electron micrographs show brush border localization |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
| Start | End | Localisation |
|---|---|---|
| 1 | 10 | Cytoplasmic |
| 11 | 32 | Membrane |
| 33 | 967 | Extracellular |
Phosphorylation
Glycosylation
Family and domain data
| Database | Domain/Family name |
|---|---|
| InterPro | Aminopeptidase_N-like_N |
| InterPro | ERAP1-like_C_dom |
| InterPro | M1_APN-typ |
| InterPro | Peptidase_M1 |
| InterPro | Peptidase_M1_dom |
| Pfam | ERAP1_C |
| Pfam | Peptidase_M1 |