Gene name
Plxnb2 (KIAA0315)
Experiment(s)
For this entry:
PLXB2_HUMAN (Plxnb2)
| Species | Homo sapiens |
|---|---|
| Localization | Basolateral plasma membrane |
| Reference |
Chin AR,Yan W,Cao M,Liu X,Wang SE (2018) Polarized Secretion of Extracellular Vesicles by Mammary Epithelia., J Mammary Gland Biol Neoplasia, 23, 165-176. [PubMed] [DOI] |
| Evidence level | Large-scale proteomics |
| Organ | Mammary gland |
| Cell | MCF10A cells (acinar cells) |
| Notes | Detected in the polarized exosome fraction |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
| Start | End | Localisation |
|---|---|---|
| 1 | 19 | Signal peptide |
| 20 | 1197 | Extracellular |
| 1198 | 1219 | Membrane |
| 1220 | 1838 | Cytoplasmic |
Phosphorylation
| Position | Resource |
|---|---|
| 126 | 36420134 |
| 200 | 55368065 |
| 419 | 3436782 |
| 452 | 18013956 |
| 650 | 55368069 |
| 1124 | 18013953 |
| 1224 | 23133344 |
| 1231 | 23133353 |
| 1244 | 12738854 |
| 1317 | 55368073 |
| 1320 | 23133347 |
| 1325 | 23133350 |
| 1327 | 17544699 |
| 1349 | 3664989 |
| 1410 | 3562596 |
| 1412 | 3662549 |
| 1422 | 3562601 |
| 1499 | 23133356 |
| 1548 | 50479811 |
| 1570 | 4719529 |
| 1614 | 11129568 |
| 1621 | 23133359 |
| 1623 | 11129572 |
| 1627 | 11129576 |
| 1756 | 55368077 |
Glycosylation
Family and domain data
| Database | Domain/Family name |
|---|---|
| InterPro | Ig-like_fold |
| InterPro | Ig_E-set |
| InterPro | IPT_dom |
| InterPro | Plexin |
| InterPro | Plexin_cytoplasmic_RasGAP_dom |
| InterPro | Plexin_repeat |
| InterPro | PSI |
| InterPro | Rho_GTPase_activation_prot |
| InterPro | Semap_dom |
| InterPro | Semap_dom_sf |
| InterPro | TIG1_plexin |
| InterPro | WD40/YVTN_repeat-like_dom_sf |
| Pfam | Plexin_cytopl |
| Pfam | PSI |
| Pfam | Sema |
| Pfam | TIG |
| Pfam | TIG_plexin |