Gene name
SLC22A5 (Octn2)
Experiment(s)
For this entry:
S22A5_HUMAN (SLC22A5)
| Species | Homo sapiens |
|---|---|
| Localization | Apical plasma membrane |
| Reference |
Garrett Q,Xu S,Simmons PA,Vehige J,Flanagan JL,Willcox MD (2008) Expression and localization of carnitine/organic cation transporter OCTN1 and OCTN2 in ocular epithelium., Invest Ophthalmol Vis Sci, 49, 4844-9. [PubMed] [DOI] |
| Evidence level | Membrane preparation |
| Organ | Cornea |
| Cell | HCLE cells (epithelial cells) |
| Notes |
S22A5_HUMAN (SLC22A5)
| Species | Homo sapiens |
|---|---|
| Localization | Apical plasma membrane |
| Reference |
Masuda S,Terada T,Yonezawa A,Tanihara Y,Kishimoto K,Katsura T,Ogawa O,Inui K (2006) Identification and functional characterization of a new human kidney-specific H+/organic cation antiporter, kidney-specific multidrug and toxin extrusion 2., J Am Soc Nephrol, 17, 2127-35. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Kidney |
| Cell | Proximal tubules |
| Notes |
S22A5_HUMAN (SLC22A5)
| Species | Homo sapiens |
|---|---|
| Localization | Apical plasma membrane |
| Reference |
Horvath G,Schmid N,Fragoso MA,Schmid A,Conner GE,Salathe M,Wanner A (2007) Epithelial organic cation transporters ensure pH-dependent drug absorption in the airway., Am J Respir Cell Mol Biol, 36, 53-60. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Lung |
| Cell | Airway epithel cells |
| Notes |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
| Start | End | Localisation |
|---|---|---|
| 1 | 19 | Cytoplasmic |
| 20 | 39 | Membrane |
| 40 | 143 | Extracellular |
| 144 | 163 | Membrane |
| 164 | 170 | Cytoplasmic |
| 171 | 190 | Membrane |
| 191 | 195 | Extracellular |
| 196 | 217 | Membrane |
| 218 | 228 | Cytoplasmic |
| 229 | 250 | Membrane |
| 251 | 257 | Extracellular |
| 258 | 277 | Membrane |
| 278 | 342 | Cytoplasmic |
| 343 | 362 | Membrane |
| 363 | 371 | Extracellular |
| 372 | 393 | Membrane |
| 394 | 400 | Cytoplasmic |
| 401 | 420 | Membrane |
| 421 | 427 | Extracellular |
| 428 | 449 | Membrane |
| 450 | 460 | Cytoplasmic |
| 461 | 482 | Membrane |
| 483 | 489 | Extracellular |
| 490 | 509 | Membrane |
| 510 | 557 | Cytoplasmic |
Phosphorylation
Glycosylation
| Position | Site resource | Glycan resource | PubMed link(s) |
|---|---|---|---|
| 57 | dbPTM | 19349973 | |
| 57 | N-GlycoSiteAtlas | 22106898 , 25247386 , 24467213 , 24495048 , 25902405 | |
| 57 | PolarProtDb | 31844046 | |
| 57 | UniPep | ||
| 57 | UniProtKB | 19349973 | |
| 64 | N-GlycoSiteAtlas | 25902405 | |
| 64 | PolarProtDb | 31844046 | |
| 91 | dbPTM | 19349973 | |
| 91 | N-GlycoSiteAtlas | 26571101 | |
| 91 | UniPep | ||
| 91 | UniProtKB | 19349973 |
Family and domain data
| Database | Domain/Family name |
|---|---|
| InterPro | MFS_dom |
| InterPro | MFS_sugar_transport-like |
| InterPro | MFS_trans_sf |
| InterPro | Orgcat_transp/SVOP |
| InterPro | Sugar_transporter_CS |
| Pfam | Sugar_tr |
Interactions
| With (links to EBI) | #Exp | PubMed links |
|---|---|---|
| KRT34_HUMAN | 3 | 32296183 |
| MTUS2_HUMAN | 3 | 32296183 |
| K1C27_HUMAN | 3 | 32296183 |
| NT2NC_HUMAN | 3 | 32296183 |
Protein can be found in apical membrane,
Protein can be found in basal membrane,
Protein can be found both membranes,
Localisation is unknown.