PolarProtDb

Gene name

SLC22A5 (Octn2)

Experiment(s)

For this entry:

S22A5_MOUSE (SLC22A5)

Species	Mus musculus
Localization	Apical plasma membrane
Reference	Watanabe C,Kato Y,Sugiura T,Kubo Y,Wakayama T,Iseki S,Tsuji A (2006) PDZ adaptor protein PDZK2 stimulates transport activity of organic cation/carnitine transporter OCTN2 by modulating cell surface expression., Drug Metab Dispos, 34, 1927-34. [PubMed] [DOI]
Evidence level	Antibody staining
Organ	Kidney
Cell	Proximal tubules
Notes	Apical localization is modulated by NHERF4 binding

For ortholog entries:

S22A5_HUMAN

A0A5F9CMA4_RABIT

Alignment and sequence features

Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).

CCTOP topology prediction

Start	End	Localisation
1	19	Cytoplasmic
20	39	Membrane
40	143	Extracellular
144	163	Membrane
164	170	Cytoplasmic
171	190	Membrane
191	196	Extracellular
197	218	Membrane
219	228	Cytoplasmic
229	250	Membrane
251	257	Extracellular
258	277	Membrane
278	342	Cytoplasmic
343	362	Membrane
363	371	Extracellular
372	393	Membrane
394	400	Cytoplasmic
401	420	Membrane
421	427	Extracellular
428	449	Membrane
450	460	Cytoplasmic
461	482	Membrane
483	488	Extracellular
489	509	Membrane
510	557	Cytoplasmic

Motifs gathered by PolarProtDb Team

Start	End	Localisation	Type	PubMed
552	557	Apical plasma membrane	PDZ-ligand	Watanabe C,Kato Y,Sugiura T,Kubo Y,Wakayama T,Iseki S,Tsuji A (2006) PDZ adaptor protein PDZK2 stimulates transport activity of organic cation/carnitine transporter OCTN2 by modulating cell surface expression., Drug Metab Dispos, 34, 1927-34. [PubMed][DOI]

Phosphorylation

Position	Resource
264	51637043
548	4786623
550	4786628

Glycosylation

Position	Site resource	Glycan resource	PubMed link(s)
64	Glyconnect	$WURCS=2.0/4,11,10/[Aad21122h-2x_2-6_5NCC/3=O][axxxxm-1x_1-5][axxxxh-1x_1-5_2NCC/3=O][axxxxh-1x_1-5]/1-2-3-3-3-4-4-4-4-4-4/a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?\|k?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?\|k?_a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?\|k?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?\|k?_a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?\|k?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?\|k?_a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?\|k?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?\|k?_a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?\|k?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?\|k?_a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?\|k?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?\|k?_a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?\|k?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?\|k?_a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?\|k?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?\|k?_a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?\|k?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?\|k?_a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?\|k?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?\|k?$	30899004
64	Glyconnect	$WURCS=2.0/2,10,9/[axxxxh-1x_1-5_2*NCC/3=O][axxxxh-1x_1-5]/1-1-2-2-2-2-2-2-2-2/a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?_a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?_a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?_a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?_a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?_a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?_a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?_a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?_a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?$	30899004

Family and domain data

Database	Domain/Family name
InterPro	MFS_dom
InterPro	MFS_sugar_transport-like
InterPro	MFS_trans_sf
InterPro	Orgcat_transp/SVOP
InterPro	Sugar_transporter_CS
Pfam	Sugar_tr