Gene name
SLC22A4 (OCTN1,ETT,UT2H)
Experiment(s)
For this entry:
S22A4_HUMAN (SLC22A4)
| Species | Homo sapiens |
|---|---|
| Localization | Apical plasma membrane |
| Reference |
Garrett Q,Xu S,Simmons PA,Vehige J,Flanagan JL,Willcox MD (2008) Expression and localization of carnitine/organic cation transporter OCTN1 and OCTN2 in ocular epithelium., Invest Ophthalmol Vis Sci, 49, 4844-9. [PubMed] [DOI] |
| Evidence level | Membrane preparation |
| Organ | Cornea |
| Cell | HCLE cells (epithelial cells) |
| Notes |
S22A4_HUMAN (SLC22A4)
| Species | Homo sapiens |
|---|---|
| Localization | Apical plasma membrane |
| Reference |
Horvath G,Schmid N,Fragoso MA,Schmid A,Conner GE,Salathe M,Wanner A (2007) Epithelial organic cation transporters ensure pH-dependent drug absorption in the airway., Am J Respir Cell Mol Biol, 36, 53-60. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Lung |
| Cell | Airway epithel cells |
| Notes |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
| Start | End | Localisation |
|---|---|---|
| 1 | 19 | Cytoplasmic |
| 20 | 39 | Membrane |
| 40 | 143 | Extracellular |
| 144 | 163 | Membrane |
| 164 | 171 | Cytoplasmic |
| 172 | 191 | Membrane |
| 192 | 196 | Extracellular |
| 197 | 217 | Membrane |
| 218 | 228 | Cytoplasmic |
| 229 | 250 | Membrane |
| 251 | 257 | Extracellular |
| 258 | 277 | Membrane |
| 278 | 340 | Cytoplasmic |
| 341 | 361 | Membrane |
| 362 | 371 | Extracellular |
| 372 | 392 | Membrane |
| 393 | 399 | Cytoplasmic |
| 400 | 419 | Membrane |
| 420 | 426 | Extracellular |
| 427 | 447 | Membrane |
| 448 | 458 | Cytoplasmic |
| 459 | 480 | Membrane |
| 481 | 486 | Extracellular |
| 487 | 507 | Membrane |
| 508 | 551 | Cytoplasmic |
Phosphorylation
Glycosylation
| Position | Site resource | Glycan resource | PubMed link(s) |
|---|---|---|---|
| 57 | N-GlycoSiteAtlas | 22106898 , 25247386 , 24467213 , 24495048 , 25902405 | |
| 57 | PolarProtDb | 31844046 | |
| 57 | UniPep | ||
| 64 | N-GlycoSiteAtlas | 24741114 , 25902405 | |
| 64 | PolarProtDb | 31844046 | |
| 91 | N-GlycoSiteAtlas | 26571101 | |
| 91 | UniPep |
Family and domain data
| Database | Domain/Family name |
|---|---|
| InterPro | MFS_dom |
| InterPro | MFS_sugar_transport-like |
| InterPro | MFS_trans_sf |
| InterPro | Orgcat_transp/SVOP |
| InterPro | Sugar_transporter_CS |
| Pfam | Sugar_tr |