Gene name
SLC22A4 (OCTN1,ETT,UT2H)
Experiment(s)
For this entry:
S22A4_MOUSE (SLC22A4)
| Species | Mus musculus |
|---|---|
| Localization | Apical plasma membrane |
| Reference |
Sugiura T,Kato S,Shimizu T,Wakayama T,Nakamichi N,Kubo Y,Iwata D,Suzuki K,Soga T,Asano M,Iseki S,Tamai I,Tsuji A,Kato Y (2010) Functional expression of carnitine/organic cation transporter OCTN1/SLC22A4 in mouse small intestine and liver., Drug Metab Dispos, 38, 1665-72. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Small intestine |
| Cell | Enterocytes |
| Notes |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
| Start | End | Localisation |
|---|---|---|
| 1 | 19 | Cytoplasmic |
| 20 | 39 | Membrane |
| 40 | 143 | Extracellular |
| 144 | 163 | Membrane |
| 164 | 171 | Cytoplasmic |
| 172 | 191 | Membrane |
| 192 | 196 | Extracellular |
| 197 | 218 | Membrane |
| 219 | 228 | Cytoplasmic |
| 229 | 250 | Membrane |
| 251 | 257 | Extracellular |
| 258 | 277 | Membrane |
| 278 | 342 | Cytoplasmic |
| 343 | 362 | Membrane |
| 363 | 371 | Extracellular |
| 372 | 393 | Membrane |
| 394 | 400 | Cytoplasmic |
| 401 | 420 | Membrane |
| 421 | 428 | Extracellular |
| 429 | 450 | Membrane |
| 451 | 460 | Cytoplasmic |
| 461 | 482 | Membrane |
| 483 | 488 | Extracellular |
| 489 | 509 | Membrane |
| 510 | 553 | Cytoplasmic |
Phosphorylation
Family and domain data
| Database | Domain/Family name |
|---|---|
| InterPro | MFS_dom |
| InterPro | MFS_sugar_transport-like |
| InterPro | MFS_trans_sf |
| InterPro | Orgcat_transp/SVOP |
| InterPro | Sugar_transporter_CS |
| Pfam | Sugar_tr |