Gene name
Abcc4 (MRP4)
Experiment(s)
For this entry:
Q6QMG6_RAT (Abcc4)
| Species | Rattus norvegicus |
|---|---|
| Localization | Basolateral plasma membrane |
| Reference |
Roberts LM,Black DS,Raman C,Woodford K,Zhou M,Haggerty JE,Yan AT,Cwirla SE,Grindstaff KK (2008) Subcellular localization of transporters along the rat blood-brain barrier and blood-cerebral-spinal fluid barrier by in vivo biotinylation., Neuroscience, 155, 423-38. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Vessels |
| Cell | Brain capillary endothelial cells |
| Notes |
Q6QMG6_RAT (Abcc4)
| Species | Rattus norvegicus |
|---|---|
| Localization | Apical plasma membrane |
| Reference |
Klein DM,Wright SH,Cherrington NJ (2014) Localization of multidrug resistance-associated proteins along the blood-testis barrier in rat, macaque, and human testis., Drug Metab Dispos, 42, 89-93. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Testis |
| Cell | Sertoli cells |
| Notes |
Q6QMG6_RAT (Abcc4)
| Species | Rattus norvegicus |
|---|---|
| Localization | Basolateral plasma membrane |
| Reference |
Rius M,Nies AT,Hummel-Eisenbeiss J,Jedlitschky G,Keppler D (2003) Cotransport of reduced glutathione with bile salts by MRP4 (ABCC4) localized to the basolateral hepatocyte membrane., Hepatology, 38, 374-84. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Liver |
| Cell | Hepatocytes |
| Notes |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
| Start | End | Localisation |
|---|---|---|
| 1 | 89 | Cytoplasmic |
| 90 | 111 | Membrane |
| 112 | 135 | Extracellular |
| 136 | 157 | Membrane |
| 158 | 208 | Cytoplasmic |
| 209 | 230 | Membrane |
| 231 | 237 | Extracellular |
| 238 | 259 | Membrane |
| 260 | 313 | Cytoplasmic |
| 314 | 334 | Membrane |
| 335 | 355 | Extracellular |
| 356 | 376 | Membrane |
| 377 | 706 | Cytoplasmic |
| 707 | 728 | Membrane |
| 729 | 766 | Extracellular |
| 767 | 787 | Membrane |
| 788 | 835 | Cytoplasmic |
| 836 | 857 | Membrane |
| 858 | 862 | Extracellular |
| 863 | 878 | Membrane |
| 879 | 946 | Cytoplasmic |
| 947 | 962 | Membrane |
| 963 | 981 | Extracellular |
| 982 | 997 | Membrane |
| 998 | 1325 | Cytoplasmic |
Phosphorylation
Family and domain data
| Database | Domain/Family name |
|---|---|
| InterPro | AAA+_ATPase |
| InterPro | ABC1_TM_dom |
| InterPro | ABC1_TM_sf |
| InterPro | ABC_transporter-like |
| InterPro | ABC_transporter_CS |
| InterPro | ABCC4 |
| InterPro | P-loop_NTPase |
| Pfam | ABC_membrane |
| Pfam | ABC_tran |