Gene name
Abcc4 (MRP4)
Experiment(s)
For this entry:
B8K1W7_CANLF (Abcc4)
| Species | Canis lupus familiaris |
|---|---|
| Localization | Basolateral plasma membrane |
| Reference |
Caceres PS,Gravotta D,Zager PJ,Dephoure N,Rodriguez-Boulan E (2019) Quantitative proteomics of MDCK cells identify unrecognized roles of clathrin adaptor AP-1 in polarized distribution of surface proteins., Proc Natl Acad Sci U S A, 116, 11796-11805. [PubMed] [DOI] |
| Evidence level | Large-scale proteomics |
| Organ | Kidney |
| Cell | MDCK cells (distal tubule) |
| Notes |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
| Start | End | Localisation |
|---|---|---|
| 1 | 90 | Cytoplasmic |
| 91 | 111 | Membrane |
| 112 | 141 | Extracellular |
| 142 | 163 | Membrane |
| 164 | 208 | Cytoplasmic |
| 209 | 230 | Membrane |
| 231 | 237 | Extracellular |
| 238 | 259 | Membrane |
| 260 | 316 | Cytoplasmic |
| 317 | 338 | Membrane |
| 339 | 368 | Extracellular |
| 369 | 390 | Membrane |
| 391 | 689 | Cytoplasmic |
| 690 | 711 | Membrane |
| 712 | 772 | Extracellular |
| 773 | 794 | Membrane |
| 795 | 837 | Cytoplasmic |
| 838 | 859 | Membrane |
| 860 | 866 | Extracellular |
| 867 | 887 | Membrane |
| 888 | 937 | Cytoplasmic |
| 938 | 962 | Membrane |
| 963 | 983 | Extracellular |
| 984 | 1011 | Membrane |
| 1012 | 1326 | Cytoplasmic |
Family and domain data
| Database | Domain/Family name |
|---|---|
| InterPro | AAA+_ATPase |
| InterPro | ABC1_TM_dom |
| InterPro | ABC1_TM_sf |
| InterPro | ABC_transporter-like |
| InterPro | ABC_transporter_CS |
| InterPro | ABCC4 |
| InterPro | P-loop_NTPase |
| Pfam | ABC_membrane |
| Pfam | ABC_tran |