Gene name
Abcc4 (MRP4)
Experiment(s)
For this entry:
MRP4_HUMAN (Abcc4)
| Species | Homo sapiens |
|---|---|
| Localization | Basolateral plasma membrane |
| Reference |
Klein DM,Wright SH,Cherrington NJ (2014) Localization of multidrug resistance-associated proteins along the blood-testis barrier in rat, macaque, and human testis., Drug Metab Dispos, 42, 89-93. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Testis |
| Cell | Sertoli cells |
| Notes |
MRP4_HUMAN (Abcc4)
| Species | Homo sapiens |
|---|---|
| Localization | Apical plasma membrane |
| Reference |
van Aubel RA,Smeets PH,Peters JG,Bindels RJ,Russel FG (2002) The MRP4/ABCC4 gene encodes a novel apical organic anion transporter in human kidney proximal tubules: putative efflux pump for urinary cAMP and cGMP., J Am Soc Nephrol, 13, 595-603. [PubMed] |
| Evidence level | Antibody staining |
| Organ | Kidney |
| Cell | Proximal tubules |
| Notes |
MRP4_HUMAN (Abcc4)
| Species | Homo sapiens |
|---|---|
| Localization | Basolateral plasma membrane |
| Reference |
Rius M,Nies AT,Hummel-Eisenbeiss J,Jedlitschky G,Keppler D (2003) Cotransport of reduced glutathione with bile salts by MRP4 (ABCC4) localized to the basolateral hepatocyte membrane., Hepatology, 38, 374-84. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Liver |
| Cell | Hepatocytes |
| Notes |
MRP4_HUMAN (Abcc4)
| Species | Homo sapiens |
|---|---|
| Localization | Basolateral plasma membrane |
| Reference |
Rius M,Nies AT,Hummel-Eisenbeiss J,Jedlitschky G,Keppler D (2003) Cotransport of reduced glutathione with bile salts by MRP4 (ABCC4) localized to the basolateral hepatocyte membrane., Hepatology, 38, 374-84. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Liver |
| Cell | HEPG2 cells (hepatocytes) |
| Notes |
MRP4_HUMAN (Abcc4)
| Species | Homo sapiens |
|---|---|
| Localization | Apical plasma membrane |
| Reference |
Nies AT,Jedlitschky G,König J,Herold-Mende C,Steiner HH,Schmitt HP,Keppler D (2004) Expression and immunolocalization of the multidrug resistance proteins, MRP1-MRP6 (ABCC1-ABCC6), in human brain., Neuroscience, 129, 349-60. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Vessels |
| Cell | Brain capillary endothelial cells |
| Notes |
MRP4_HUMAN (Abcc4)
| Species | Homo sapiens |
|---|---|
| Localization | Basolateral plasma membrane |
| Reference |
König J,Hartel M,Nies AT,Martignoni ME,Guo J,Büchler MW,Friess H,Keppler D (2005) Expression and localization of human multidrug resistance protein (ABCC) family members in pancreatic carcinoma., Int J Cancer, 115, 359-67. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Pancreas |
| Cell | Ductal cells |
| Notes |
MRP4_HUMAN (Abcc4)
| Species | Homo sapiens |
|---|---|
| Localization | Basolateral plasma membrane |
| Reference |
Ming X,Thakker DR (2010) Role of basolateral efflux transporter MRP4 in the intestinal absorption of the antiviral drug adefovir dipivoxil., Biochem Pharmacol, 79, 455-62. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Large intestine |
| Cell | CACO-2 cells (enterocytes) |
| Notes |
MRP4_HUMAN (Abcc4)
| Species | Homo sapiens |
|---|---|
| Localization | Apical plasma membrane |
| Reference |
Azzaroli F,Mennone A,Feletti V,Simoni P,Baglivo E,Montagnani M,Rizzo N,Pelusi G,DE Aloysio D,Lodato F,Festi D,Colecchia A,Roda E,Boyer JL,Mazzella G (2007) Clinical trial: modulation of human placental multidrug resistance proteins in cholestasis of pregnancy by ursodeoxycholic acid., Aliment Pharmacol Ther, 26, 1139-46. [PubMed] [DOI] |
| Evidence level | Membrane preparation |
| Organ | Placenta |
| Cell | Trophoblast cells |
| Notes |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
| Start | End | Localisation |
|---|---|---|
| 1 | 89 | Cytoplasmic |
| 90 | 111 | Membrane |
| 112 | 135 | Extracellular |
| 136 | 157 | Membrane |
| 158 | 208 | Cytoplasmic |
| 209 | 229 | Membrane |
| 230 | 241 | Extracellular |
| 242 | 258 | Membrane |
| 259 | 318 | Cytoplasmic |
| 319 | 340 | Membrane |
| 341 | 354 | Extracellular |
| 355 | 376 | Membrane |
| 377 | 708 | Cytoplasmic |
| 709 | 730 | Membrane |
| 731 | 766 | Extracellular |
| 767 | 787 | Membrane |
| 788 | 837 | Cytoplasmic |
| 838 | 858 | Membrane |
| 859 | 865 | Extracellular |
| 866 | 882 | Membrane |
| 883 | 936 | Cytoplasmic |
| 937 | 957 | Membrane |
| 958 | 981 | Extracellular |
| 982 | 997 | Membrane |
| 998 | 1325 | Cytoplasmic |
Phosphorylation
Glycosylation
| Position | Site resource | Glycan resource | PubMed link(s) |
|---|---|---|---|
| 746 | N-GlycoSiteAtlas | 22494190 | |
| 746 | PolarProtDb | 31844046 | |
| 754 | N-GlycoSiteAtlas | 22494190 | |
| 754 | PolarProtDb | 31844046 |
Family and domain data
| Database | Domain/Family name |
|---|---|
| InterPro | AAA+_ATPase |
| InterPro | ABC1_TM_dom |
| InterPro | ABC1_TM_sf |
| InterPro | ABC_transporter-like |
| InterPro | ABC_transporter_CS |
| InterPro | ABCC4 |
| InterPro | P-loop_NTPase |
| Pfam | ABC_membrane |
| Pfam | ABC_tran |