Gene name
Abcc4 (MRP4)
Experiment(s)
For this entry:
F7ENH5_MACMU (Abcc4)
| Species | Macaca mulatta |
|---|---|
| Localization | Basolateral plasma membrane |
| Reference |
Klein DM,Wright SH,Cherrington NJ (2014) Localization of multidrug resistance-associated proteins along the blood-testis barrier in rat, macaque, and human testis., Drug Metab Dispos, 42, 89-93. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Testis |
| Cell | Sertoli cells |
| Notes |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
| Start | End | Localisation |
|---|---|---|
| 1 | 89 | Cytoplasmic |
| 90 | 111 | Membrane |
| 112 | 135 | Extracellular |
| 136 | 157 | Membrane |
| 158 | 209 | Cytoplasmic |
| 210 | 233 | Membrane |
| 234 | 240 | Extracellular |
| 241 | 258 | Membrane |
| 259 | 317 | Cytoplasmic |
| 318 | 339 | Membrane |
| 340 | 354 | Extracellular |
| 355 | 376 | Membrane |
| 377 | 708 | Cytoplasmic |
| 709 | 730 | Membrane |
| 731 | 766 | Extracellular |
| 767 | 787 | Membrane |
| 788 | 837 | Cytoplasmic |
| 838 | 858 | Membrane |
| 859 | 865 | Extracellular |
| 866 | 882 | Membrane |
| 883 | 936 | Cytoplasmic |
| 937 | 957 | Membrane |
| 958 | 981 | Extracellular |
| 982 | 997 | Membrane |
| 998 | 1325 | Cytoplasmic |
Family and domain data
| Database | Domain/Family name |
|---|---|
| InterPro | AAA+_ATPase |
| InterPro | ABC1_TM_dom |
| InterPro | ABC1_TM_sf |
| InterPro | ABC_transporter-like |
| InterPro | ABC_transporter_CS |
| InterPro | ABCC4 |
| InterPro | P-loop_NTPase |
| Pfam | ABC_membrane |
| Pfam | ABC_tran |