Gene name
Abcc1 (Mrp,Mrp1,Abcc1a,Abcc1b,Mdrap)
Experiment(s)
For this entry:
MRP1_RAT (Abcc1)
| Species | Rattus norvegicus |
|---|---|
| Localization | Basolateral plasma membrane |
| Reference |
Rao VV,Dahlheimer JL,Bardgett ME,Snyder AZ,Finch RA,Sartorelli AC,Piwnica-Worms D (1999) Choroid plexus epithelial expression of MDR1 P glycoprotein and multidrug resistance-associated protein contribute to the blood-cerebrospinal-fluid drug-permeability barrier., Proc Natl Acad Sci U S A, 96, 3900-5. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Choroid plexus |
| Cell | Ependymal cells |
| Notes |
MRP1_RAT (Abcc1)
| Species | Rattus norvegicus |
|---|---|
| Localization | Basolateral plasma membrane |
| Reference |
Emi Y,Yasuda Y,Sakaguchi M (2012) A cis-acting five-amino-acid motif controls targeting of ABCC2 to the apical plasma membrane domain., J Cell Sci, 125, 3133-43. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Liver |
| Cell | HEPG2 cells (hepatocytes) |
| Notes | A MYC tag was used for labelling |
MRP1_RAT (Abcc1)
| Species | Rattus norvegicus |
|---|---|
| Localization | Basolateral plasma membrane |
| Reference |
Roberts LM,Black DS,Raman C,Woodford K,Zhou M,Haggerty JE,Yan AT,Cwirla SE,Grindstaff KK (2008) Subcellular localization of transporters along the rat blood-brain barrier and blood-cerebral-spinal fluid barrier by in vivo biotinylation., Neuroscience, 155, 423-38. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Vessels |
| Cell | Brain capillary endothelial cells |
| Notes |
MRP1_RAT (Abcc1)
| Species | Rattus norvegicus |
|---|---|
| Localization | Basolateral plasma membrane |
| Reference |
Klein DM,Wright SH,Cherrington NJ (2014) Localization of multidrug resistance-associated proteins along the blood-testis barrier in rat, macaque, and human testis., Drug Metab Dispos, 42, 89-93. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Testis |
| Cell | Sertoli cells |
| Notes |
MRP1_RAT (Abcc1)
| Species | Rattus norvegicus |
|---|---|
| Localization | Basolateral plasma membrane |
| Reference |
St-Pierre MV,Stallmach T,Freimoser Grundschober A,Dufour JF,Serrano MA,Marin JJ,Sugiyama Y,Meier PJ (2004) Temporal expression profiles of organic anion transport proteins in placenta and fetal liver of the rat., Am J Physiol Regul Integr Comp Physiol, 287, R1505-16. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Placenta |
| Cell | Trophoblast cells |
| Notes |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
| Start | End | Localisation |
|---|---|---|
| 1 | 35 | Extracellular |
| 36 | 56 | Membrane |
| 57 | 72 | Cytoplasmic |
| 73 | 93 | Membrane |
| 94 | 103 | Extracellular |
| 104 | 124 | Membrane |
| 125 | 135 | Cytoplasmic |
| 136 | 156 | Membrane |
| 157 | 172 | Extracellular |
| 173 | 191 | Membrane |
| 192 | 320 | Cytoplasmic |
| 321 | 341 | Membrane |
| 342 | 364 | Extracellular |
| 365 | 386 | Membrane |
| 387 | 439 | Cytoplasmic |
| 440 | 460 | Membrane |
| 461 | 464 | Extracellular |
| 465 | 485 | Membrane |
| 486 | 548 | Cytoplasmic |
| 549 | 570 | Membrane |
| 571 | 582 | Extracellular |
| 583 | 604 | Membrane |
| 605 | 968 | Cytoplasmic |
| 969 | 990 | Membrane |
| 991 | 1020 | Extracellular |
| 1021 | 1042 | Membrane |
| 1043 | 1091 | Cytoplasmic |
| 1092 | 1112 | Membrane |
| 1113 | 1114 | Extracellular |
| 1115 | 1135 | Membrane |
| 1136 | 1198 | Cytoplasmic |
| 1199 | 1220 | Membrane |
| 1221 | 1227 | Extracellular |
| 1228 | 1249 | Membrane |
| 1250 | 1532 | Cytoplasmic |
Phosphorylation
Family and domain data
| Database | Domain/Family name |
|---|---|
| InterPro | AAA+_ATPase |
| InterPro | ABC1_TM_dom |
| InterPro | ABC1_TM_sf |
| InterPro | ABC_transporter-like |
| InterPro | ABC_transporter_CS |
| InterPro | Aldo/ket_reductase_CS |
| InterPro | Multidrug-R_assoc |
| InterPro | P-loop_NTPase |
| Pfam | ABC_membrane |
| Pfam | ABC_tran |