Gene name
Abcc1 (Mrp,Mrp1,Abcc1a,Abcc1b,Mdrap)
Experiment(s)
For this entry:
MRP1_MOUSE (Abcc1)
| Species | Mus musculus |
|---|---|
| Localization | Basolateral plasma membrane |
| Reference |
Peng KC,Cluzeaud F,Bens M,Duong Van Huyen JP,Wioland MA,Lacave R,Vandewalle A (1999) Tissue and cell distribution of the multidrug resistance-associated protein (MRP) in mouse intestine and kidney., J Histochem Cytochem, 47, 757-68. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Small intestine |
| Cell | Crypt gland cells |
| Notes |
MRP1_MOUSE (Abcc1)
| Species | Mus musculus |
|---|---|
| Localization | Basolateral plasma membrane |
| Reference |
Peng KC,Cluzeaud F,Bens M,Duong Van Huyen JP,Wioland MA,Lacave R,Vandewalle A (1999) Tissue and cell distribution of the multidrug resistance-associated protein (MRP) in mouse intestine and kidney., J Histochem Cytochem, 47, 757-68. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Kidney |
| Cell | Collecting ducts |
| Notes |
MRP1_MOUSE (Abcc1)
| Species | Mus musculus |
|---|---|
| Localization | Basolateral plasma membrane |
| Reference |
Peng KC,Cluzeaud F,Bens M,Duong Van Huyen JP,Wioland MA,Lacave R,Vandewalle A (1999) Tissue and cell distribution of the multidrug resistance-associated protein (MRP) in mouse intestine and kidney., J Histochem Cytochem, 47, 757-68. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Kidney |
| Cell | Distal tubules |
| Notes |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
| Start | End | Localisation |
|---|---|---|
| 1 | 36 | Extracellular |
| 37 | 55 | Membrane |
| 56 | 74 | Cytoplasmic |
| 75 | 94 | Membrane |
| 95 | 104 | Extracellular |
| 105 | 125 | Membrane |
| 126 | 135 | Cytoplasmic |
| 136 | 156 | Membrane |
| 157 | 172 | Extracellular |
| 173 | 191 | Membrane |
| 192 | 321 | Cytoplasmic |
| 322 | 343 | Membrane |
| 344 | 364 | Extracellular |
| 365 | 386 | Membrane |
| 387 | 438 | Cytoplasmic |
| 439 | 460 | Membrane |
| 461 | 465 | Extracellular |
| 466 | 485 | Membrane |
| 486 | 548 | Cytoplasmic |
| 549 | 570 | Membrane |
| 571 | 582 | Extracellular |
| 583 | 604 | Membrane |
| 605 | 964 | Cytoplasmic |
| 965 | 986 | Membrane |
| 987 | 1016 | Extracellular |
| 1017 | 1038 | Membrane |
| 1039 | 1087 | Cytoplasmic |
| 1088 | 1108 | Membrane |
| 1109 | 1110 | Extracellular |
| 1111 | 1131 | Membrane |
| 1132 | 1194 | Cytoplasmic |
| 1195 | 1216 | Membrane |
| 1217 | 1223 | Extracellular |
| 1224 | 1245 | Membrane |
| 1246 | 1528 | Cytoplasmic |
Phosphorylation
Family and domain data
| Database | Domain/Family name |
|---|---|
| InterPro | AAA+_ATPase |
| InterPro | ABC1_TM_dom |
| InterPro | ABC1_TM_sf |
| InterPro | ABC_transporter-like |
| InterPro | ABC_transporter_CS |
| InterPro | Multidrug-R_assoc |
| InterPro | P-loop_NTPase |
| Pfam | ABC_membrane |
| Pfam | ABC_tran |