Gene name
Abcc1 (Mrp,Mrp1,Abcc1a,Abcc1b,Mdrap)
Experiment(s)
For this entry:
MRP1_HUMAN (Abcc1)
| Species | Homo sapiens |
|---|---|
| Localization | Basolateral plasma membrane |
| Reference |
Klein DM,Wright SH,Cherrington NJ (2014) Localization of multidrug resistance-associated proteins along the blood-testis barrier in rat, macaque, and human testis., Drug Metab Dispos, 42, 89-93. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Testis |
| Cell | Sertoli cells |
| Notes |
MRP1_HUMAN (Abcc1)
| Species | Homo sapiens |
|---|---|
| Localization | Basolateral plasma membrane |
| Reference |
Evers R,Zaman GJ,van Deemter L,Jansen H,Calafat J,Oomen LC,Oude Elferink RP,Borst P,Schinkel AH (1996) Basolateral localization and export activity of the human multidrug resistance-associated protein in polarized pig kidney cells., J Clin Invest, 97, 1211-8. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Kidney |
| Cell | LLC-PK1 cells (proximal tubule) |
| Notes |
MRP1_HUMAN (Abcc1)
| Species | Homo sapiens |
|---|---|
| Localization | Basolateral plasma membrane |
| Reference |
Roelofsen H,Vos TA,Schippers IJ,Kuipers F,Koning H,Moshage H,Jansen PL,Müller M (1997) Increased levels of the multidrug resistance protein in lateral membranes of proliferating hepatocyte-derived cells., Gastroenterology, 112, 511-21. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Liver |
| Cell | HEPG2 cells (hepatocytes) |
| Notes |
MRP1_HUMAN (Abcc1)
| Species | Homo sapiens |
|---|---|
| Localization | Basolateral plasma membrane |
| Reference |
Bakos E,Evers R,Szakács G,Tusnády GE,Welker E,Szabó K,de Haas M,van Deemter L,Borst P,Váradi A,Sarkadi B (1998) Functional multidrug resistance protein (MRP1) lacking the N-terminal transmembrane domain., J Biol Chem, 273, 32167-75. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Kidney |
| Cell | MDCK cells (distal tubule) |
| Notes |
MRP1_HUMAN (Abcc1)
| Species | Homo sapiens |
|---|---|
| Localization | Apical plasma membrane |
| Reference |
St-Pierre MV,Serrano MA,Macias RI,Dubs U,Hoechli M,Lauper U,Meier PJ,Marin JJ (2000) Expression of members of the multidrug resistance protein family in human term placenta., Am J Physiol Regul Integr Comp Physiol, 279, R1495-503. [PubMed] [DOI] |
| Evidence level | Membrane preparation |
| Organ | Placenta |
| Cell | Trophoblast cells |
| Notes |
MRP1_HUMAN (Abcc1)
| Species | Homo sapiens |
|---|---|
| Localization | Basolateral plasma membrane |
| Reference |
Nagashige M,Ushigome F,Koyabu N,Hirata K,Kawabuchi M,Hirakawa T,Satoh S,Tsukimori K,Nakano H,Uchiumi T,Kuwano M,Ohtani H,Sawada Y (2003) Basal membrane localization of MRP1 in human placental trophoblast., Placenta, 24, 951-8. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Placenta |
| Cell | Trophoblast cells |
| Notes |
MRP1_HUMAN (Abcc1)
| Species | Homo sapiens |
|---|---|
| Localization | Basolateral plasma membrane |
| Reference |
Bart J,Hollema H,Groen HJ,de Vries EG,Hendrikse NH,Sleijfer DT,Wegman TD,Vaalburg W,van der Graaf WT (2004) The distribution of drug-efflux pumps, P-gp, BCRP, MRP1 and MRP2, in the normal blood-testis barrier and in primary testicular tumours., Eur J Cancer, 40, 2064-70. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Testis |
| Cell | Sertoli cells |
| Notes |
MRP1_HUMAN (Abcc1)
| Species | Homo sapiens |
|---|---|
| Localization | Apical plasma membrane |
| Reference |
Nies AT,Jedlitschky G,König J,Herold-Mende C,Steiner HH,Schmitt HP,Keppler D (2004) Expression and immunolocalization of the multidrug resistance proteins, MRP1-MRP6 (ABCC1-ABCC6), in human brain., Neuroscience, 129, 349-60. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Vessels |
| Cell | Brain capillary endothelial cells |
| Notes |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
| Start | End | Localisation |
|---|---|---|
| 1 | 35 | Extracellular |
| 36 | 56 | Membrane |
| 57 | 74 | Cytoplasmic |
| 75 | 94 | Membrane |
| 95 | 104 | Extracellular |
| 105 | 125 | Membrane |
| 126 | 135 | Cytoplasmic |
| 136 | 156 | Membrane |
| 157 | 172 | Extracellular |
| 173 | 191 | Membrane |
| 192 | 320 | Cytoplasmic |
| 321 | 342 | Membrane |
| 343 | 363 | Extracellular |
| 364 | 385 | Membrane |
| 386 | 438 | Cytoplasmic |
| 439 | 459 | Membrane |
| 460 | 463 | Extracellular |
| 464 | 484 | Membrane |
| 485 | 547 | Cytoplasmic |
| 548 | 569 | Membrane |
| 570 | 581 | Extracellular |
| 582 | 603 | Membrane |
| 604 | 968 | Cytoplasmic |
| 969 | 990 | Membrane |
| 991 | 1016 | Extracellular |
| 1017 | 1038 | Membrane |
| 1039 | 1090 | Cytoplasmic |
| 1091 | 1111 | Membrane |
| 1112 | 1113 | Extracellular |
| 1114 | 1134 | Membrane |
| 1135 | 1197 | Cytoplasmic |
| 1198 | 1219 | Membrane |
| 1220 | 1226 | Extracellular |
| 1227 | 1248 | Membrane |
| 1249 | 1531 | Cytoplasmic |
Phosphorylation
| Position | Resource |
|---|---|
| 249 | 25592000 |
| 277 | 3699303 |
| 279 | 23078351 |
| 289 | 4696926 |
| 404 | 34372053 |
| 497 | 31081717 |
| 847 | 36275211 |
| 852 | 55371942 |
| 871 | 62463402 |
| 872 | 55371946 |
| 905 | 18006287 |
| 915 | 3878526 |
| 916 | 9183910 |
| 917 | 10794989 |
| 918 | 4696950 |
| 919 | 4696955 |
| 920 | 461998 |
| 921 | 4696960 |
| 925 | 4696965 |
| 930 | 4149051 |
| 931 | 11091047 |
| 961 | 62463401 |
| 1145 | 27442783 |
| 1243 | 21690006 |
| 1508 | 2470205 |
| 1522 | 3972428 |
| 1523 | 15417460 |
Glycosylation
| Position | Site resource | Glycan resource | PubMed link(s) |
|---|---|---|---|
| 19 | dbPTM | 9295302 | |
| 19 | UniProtKB | 9295302 | |
| 23 | dbPTM | 9295302 | |
| 23 | N-GlycoSiteAtlas | 26571101 | |
| 23 | UniProtKB | 9295302 | |
| 354 | N-GlycoSiteAtlas | 24324730 , 24721674 | |
| 1006 | dbPTM | 9295302 | |
| 1006 | N-GlycoSiteAtlas | ||
| 1006 | PolarProtDb | 31844046 | |
| 1006 | UniPep | ||
| 1006 | UniProtKB | 9295302 |
Family and domain data
| Database | Domain/Family name |
|---|---|
| InterPro | AAA+_ATPase |
| InterPro | ABC1_TM_dom |
| InterPro | ABC1_TM_sf |
| InterPro | ABC_transporter-like |
| InterPro | ABC_transporter_CS |
| InterPro | Multidrug-R_assoc |
| InterPro | P-loop_NTPase |
| Pfam | ABC_membrane |
| Pfam | ABC_tran |
Interactions
| With (links to EBI) | #Exp | PubMed links |
|---|---|---|
| TMM17_HUMAN | 2 | 26638075 |
Protein can be found in apical membrane,
Protein can be found in basal membrane,
Protein can be found both membranes,
Localisation is unknown.