Gene name
Lrp2
Experiment(s)
For this entry:
LRP2_MOUSE (Lrp2)
Species | Mus musculus |
---|---|
Localization | Apical plasma membrane |
Reference |
Strope S,Rivi R,Metzger T,Manova K,Lacy E (2004) Mouse amnionless, which is required for primitive streak assembly, mediates cell-surface localization and endocytic function of cubilin on visceral endoderm and kidney proximal tubules., Development, 131, 4787-95. [PubMed] [DOI] |
Evidence level | Antibody staining |
Organ | Embryonic epithel |
Cell | Visceral endoderm cells |
Notes | Localization did not depend on the AMNS-CUBN complex |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
Start | End | Localisation |
---|---|---|
1 | 25 | Signal peptide |
26 | 4425 | Extracellular |
4426 | 4447 | Membrane |
4448 | 4660 | Cytoplasmic |
Phosphorylation
Glycosylation
Family and domain data
Database | Domain/Family name |
---|---|
InterPro | 6-blade_b-propeller_TolB-like |
InterPro | cEGF |
InterPro | EGF-like_Ca-bd_dom |
InterPro | EGF-like_dom |
InterPro | EGF-type_Asp/Asn_hydroxyl_site |
InterPro | EGF_Ca-bd_CS |
InterPro | Growth_fac_rcpt_cys_sf |
InterPro | LDL_receptor-like_sf |
InterPro | LDLR_class-A_CS |
InterPro | LDLR_classB_rpt |
InterPro | LDrepeatLR_classA_rpt |
Pfam | cEGF |
Pfam | EGF_CA |
Pfam | Ldl_recept_a |
Pfam | Ldl_recept_b |
Interactions
With (links to EBI) | #Exp | PubMed links |
---|---|---|
SYJ2B_MOUSE | 2 | 10827173 |
JIP2_MOUSE | 2 | 10827173 |
DAB1_MOUSE | 2 | 10827173 |
DLG4_MOUSE | 2 | 10827173 |
GIPC1_MOUSE | 2 | 10827173 |
JIP1_MOUSE | 2 | 10827173 |
Protein can be found in apical membrane,
Protein can be found in basal membrane,
Protein can be found both membranes,
Localisation is unknown.