Gene name

Lrp2

Experiment(s)

For this entry:
LRP2_MOUSE (Lrp2)
Species Mus musculus
Localization Apical plasma membrane
Reference Strope S,Rivi R,Metzger T,Manova K,Lacy E (2004) Mouse amnionless, which is required for primitive streak assembly, mediates cell-surface localization and endocytic function of cubilin on visceral endoderm and kidney proximal tubules., Development, 131, 4787-95.
[PubMed] [DOI]
Evidence level Antibody staining
Organ Embryonic epithel
Cell Visceral endoderm cells
Notes Localization did not depend on the AMNS-CUBN complex
For ortholog entries:

Alignment and sequence features

Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
Start End Localisation
1 25 Signal peptide
26 4425 Extracellular
4426 4447 Membrane
4448 4660 Cytoplasmic
Phosphorylation
Glycosylation

Family and domain data

Database Domain/Family name
InterPro 6-blade_b-propeller_TolB-like
InterPro cEGF
InterPro EGF-like_Ca-bd_dom
InterPro EGF-like_dom
InterPro EGF-type_Asp/Asn_hydroxyl_site
InterPro EGF_Ca-bd_CS
InterPro Growth_fac_rcpt_cys_sf
InterPro LDL_receptor-like_sf
InterPro LDLR_class-A_CS
InterPro LDLR_classB_rpt
InterPro LDrepeatLR_classA_rpt
Pfam cEGF
Pfam EGF_CA
Pfam Ldl_recept_a
Pfam Ldl_recept_b

Interactions

With (links to EBI) #Exp PubMed links
SYJ2B_MOUSE 2 10827173
JIP2_MOUSE 2 10827173
DAB1_MOUSE 2 10827173
DLG4_MOUSE 2 10827173
GIPC1_MOUSE 2 10827173
JIP1_MOUSE 2 10827173
Protein can be found in apical membrane, Protein can be found in basal membrane, Protein can be found both membranes, Localisation is unknown.

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