Gene name
Lrp2
Experiment(s)
For this entry:
LRP2_HUMAN (Lrp2)
| Species | Homo sapiens |
|---|---|
| Localization | Apical plasma membrane |
| Reference |
Perez Bay AE,Schreiner R,Benedicto I,Paz Marzolo M,Banfelder J,Weinstein AM,Rodriguez-Boulan EJ (2016) The fast-recycling receptor Megalin defines the apical recycling pathway of epithelial cells., Nat Commun, 7, 11550. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Kidney |
| Cell | MDCK cells (distal tubule) |
| Notes | A HA tag was used for labelling the mini-receptor |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
| Start | End | Localisation |
|---|---|---|
| 1 | 25 | Signal peptide |
| 26 | 4423 | Extracellular |
| 4424 | 4446 | Membrane |
| 4447 | 4655 | Cytoplasmic |
Phosphorylation
| Position | Resource |
|---|---|
| 563 | 23122879 |
| 572 | 5546983 |
| 580 | 5546988 |
| 586 | 5546993 |
| 805 | 4114874 |
| 897 | 23122870 |
| 898 | 23122882 |
| 1030 | 23122855 |
| 1414 | 34350043 |
| 1417 | 34350046 |
| 1419 | 34350049 |
| 1423 | 34350052 |
| 1638 | 23122858 |
| 1902 | 23122861 |
| 1912 | 23122873 |
| 2010 | 36419651 |
| 2704 | 25299049 |
| 3021 | 23122885 |
| 3022 | 23122864 |
| 3029 | 23122888 |
| 3031 | 23122876 |
| 4028 | 25299046 |
| 4104 | 34364132 |
| 4181 | 23122867 |
| 4308 | 34356176 |
| 4451 | 25299043 |
| 4463 | 484197 |
| 4478 | 767906 |
| 4481 | 56656271 |
| 4526 | 11168148 |
| 4527 | 767902 |
| 4569 | 4689546 |
| 4587 | 767905 |
| 4598 | 473715 |
| 4608 | 33526123 |
| 4612 | 33526177 |
| 4616 | 767904 |
| 4627 | 767903 |
| 4634 | 15411888 |
| 4635 | 473716 |
| 4636 | 25299040 |
| 4638 | 18504981 |
| 4641 | 767907 |
| 4645 | 25299037 |
| 4653 | 4689581 |
Glycosylation
Family and domain data
| Database | Domain/Family name |
|---|---|
| InterPro | 6-blade_b-propeller_TolB-like |
| InterPro | cEGF |
| InterPro | EGF-like_Ca-bd_dom |
| InterPro | EGF-like_dom |
| InterPro | EGF-type_Asp/Asn_hydroxyl_site |
| InterPro | EGF_Ca-bd_CS |
| InterPro | Growth_fac_rcpt_cys_sf |
| InterPro | LDL_receptor-like_sf |
| InterPro | LDLR_class-A_CS |
| InterPro | LDLR_classB_rpt |
| InterPro | LDrepeatLR_classA_rpt |
| InterPro | Lectin_legB_Mn/Ca_BS |
| Pfam | cEGF |
| Pfam | EGF_CA |
| Pfam | Ldl_recept_a |
| Pfam | Ldl_recept_b |