Gene name
Lrp1 (A2MR,APR)
Experiment(s)
For this entry:
LRP1_HUMAN (Lrp1)
Species | Homo sapiens |
---|---|
Localization | Basolateral plasma membrane |
Reference |
Donoso M,Cancino J,Lee J,van Kerkhof P,Retamal C,Bu G,Gonzalez A,Cáceres A,Marzolo MP (2009) Polarized traffic of LRP1 involves AP1B and SNX17 operating on Y-dependent sorting motifs in different pathways., Mol Biol Cell, 20, 481-97. [PubMed] [DOI] |
Evidence level | Antibody staining + sub-protein manipulation |
Organ | Kidney |
Cell | MDCK cells (distal tubule) |
Notes | A shortened LRP1 protein construct was used. Basolateral targeting relied on an NPxY-type sorting motif |
LRP1_HUMAN (Lrp1)
Species | Homo sapiens |
---|---|
Localization | Basolateral plasma membrane |
Reference |
Donoso M,Cancino J,Lee J,van Kerkhof P,Retamal C,Bu G,Gonzalez A,Cáceres A,Marzolo MP (2009) Polarized traffic of LRP1 involves AP1B and SNX17 operating on Y-dependent sorting motifs in different pathways., Mol Biol Cell, 20, 481-97. [PubMed] [DOI] |
Evidence level | Antibody staining + sub-protein manipulation |
Organ | Thyroid gland |
Cell | FRT cells (follicular cells) |
Notes | A shortened LRP1 protein construct was used |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
Start | End | Localisation |
---|---|---|
1 | 19 | Signal peptide |
20 | 4422 | Extracellular |
4423 | 4443 | Membrane |
4444 | 4544 | Cytoplasmic |
Motifs gathered by PolarProtDb Team
Start | End | Localisation | Type | PubMed |
---|---|---|---|---|
4500 | 4510 | Basolateral plasma membrane | NPxY type |
Donoso M,Cancino J,Lee J,van Kerkhof P,Retamal C,Bu G,Gonzalez A,Cáceres A,Marzolo MP (2009) Polarized traffic of LRP1 involves AP1B and SNX17 operating on Y-dependent sorting motifs in different pathways., Mol Biol Cell, 20, 481-97. [PubMed][DOI] |
4506 | 4511 | Basolateral plasma membrane | Tyrosine |
Donoso M,Cancino J,Lee J,van Kerkhof P,Retamal C,Bu G,Gonzalez A,Cáceres A,Marzolo MP (2009) Polarized traffic of LRP1 involves AP1B and SNX17 operating on Y-dependent sorting motifs in different pathways., Mol Biol Cell, 20, 481-97. [PubMed][DOI] |
Phosphorylation
Position | Resource |
---|---|
511 | 27452331 |
530 | 23122809 |
648 | 23122803 |
1417 | 195033562 |
1419 | 54218134 |
1430 | 25299005 |
1432 | 25299009 |
1440 | 25299011 |
1443 | 25299013 |
1498 | 23122797 |
1500 | 3072959 |
1513 | 3072659 |
1587 | 10788669 |
1754 | 23122785 |
1790 | 18911546 |
2156 | 25299007 |
2290 | 477480 |
2559 | 50782835 |
2560 | 50782843 |
2563 | 50782839 |
2621 | 23122788 |
3142 | 34359499 |
3261 | 31865940 |
3928 | 23122791 |
4067 | 23122794 |
4071 | 18911549 |
4249 | 22351420 |
4460 | 12526700 |
4473 | 473712 |
4507 | 451245 |
4511 | 23122806 |
4517 | 4769100 |
4520 | 450168 |
4523 | 7103863 |