Gene name
DPP4 (CD26,ADCP2)
Experiment(s)
For this entry:
DPP4_HUMAN (DPP4)
Species | Homo sapiens |
---|---|
Localization | Apical plasma membrane |
Reference |
Pshezhetsky AV,Fedjaev M,Ashmarina L,Mazur A,Budman L,Sinnett D,Labuda D,Beaulieu JF,Ménard D,Nifant'ev I,Levy E (2007) Subcellular proteomics of cell differentiation: quantitative analysis of the plasma membrane proteome of Caco-2 cells., Proteomics, 7, 2201-15. [PubMed] [DOI] |
Evidence level | Large-scale proteomics |
Organ | Large intestine |
Cell | CACO-2 cells (enterocytes) |
Notes | Cutoff: at least 4-fold enrichment (A/total) at any repetition |
DPP4_HUMAN (DPP4)
Species | Homo sapiens |
---|---|
Localization | Apical plasma membrane |
Reference |
Wojtal KA,de Vries E,Hoekstra D,van Ijzendoorn SC (2006) Efficient trafficking of MDR1/P-glycoprotein to apical canalicular plasma membranes in HepG2 cells requires PKA-RIIalpha anchoring and glucosylceramide., Mol Biol Cell, 17, 3638-50. [PubMed] [DOI] |
Evidence level | Antibody staining |
Organ | Liver |
Cell | HEPG2 cells (hepatocytes) |
Notes |
DPP4_HUMAN (DPP4)
Species | Homo sapiens |
---|---|
Localization | Apical plasma membrane |
Reference |
Nies AT,Herrmann E,Brom M,Keppler D (2008) Vectorial transport of the plant alkaloid berberine by double-transfected cells expressing the human organic cation transporter 1 (OCT1, SLC22A1) and the efflux pump MDR1 P-glycoprotein (ABCB1)., Naunyn Schmiedebergs Arch Pharmacol, 376, 449-61. [PubMed] [DOI] |
Evidence level | Antibody staining |
Organ | Kidney |
Cell | Proximal tubules |
Notes |
DPP4_HUMAN (DPP4)
Species | Homo sapiens |
---|---|
Localization | Apical plasma membrane |
Reference |
Nies AT,Herrmann E,Brom M,Keppler D (2008) Vectorial transport of the plant alkaloid berberine by double-transfected cells expressing the human organic cation transporter 1 (OCT1, SLC22A1) and the efflux pump MDR1 P-glycoprotein (ABCB1)., Naunyn Schmiedebergs Arch Pharmacol, 376, 449-61. [PubMed] [DOI] |
Evidence level | Antibody staining |
Organ | Liver |
Cell | Hepatocytes |
Notes |
DPP4_HUMAN (DPP4)
Species | Homo sapiens |
---|---|
Localization | Apical plasma membrane |
Reference |
König J,Cui Y,Nies AT,Keppler D (2000) Localization and genomic organization of a new hepatocellular organic anion transporting polypeptide., J Biol Chem, 275, 23161-8. [PubMed] [DOI] |
Evidence level | Antibody staining |
Organ | Liver |
Cell | Hepatocytes |
Notes |
DPP4_HUMAN (DPP4)
Species | Homo sapiens |
---|---|
Localization | Apical plasma membrane |
Reference |
Schaub TP,Kartenbeck J,König J,Spring H,Dörsam J,Staehler G,Störkel S,Thon WF,Keppler D (1999) Expression of the MRP2 gene-encoded conjugate export pump in human kidney proximal tubules and in renal cell carcinoma., J Am Soc Nephrol, 10, 1159-69. [PubMed] |
Evidence level | Antibody staining |
Organ | Kidney |
Cell | Proximal tubules |
Notes |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
Start | End | Localisation |
---|---|---|
1 | 6 | Cytoplasmic |
7 | 26 | Membrane |
27 | 766 | Extracellular |
Phosphorylation
Glycosylation
Family and domain data
Database | Domain/Family name |
---|---|
InterPro | AB_hydrolase |
InterPro | Pept_S9_AS |
InterPro | Peptidase_S9 |
InterPro | Peptidase_S9B_N |
InterPro | Peptidase_S9B_N_sf |
Pfam | DPPIV_N |
Pfam | Peptidase_S9 |
Interactions
With (links to EBI) | #Exp | PubMed links |
---|---|---|
SPIKE_MERS1 | 6 | 32203189 , 32275855 , 29669833 |
A0A2R4KP93_MERS | 2 | 29669833 |
Protein can be found in apical membrane,
Protein can be found in basal membrane,
Protein can be found both membranes,
Localisation is unknown.