Gene name
CD44 (LHR,MDU2,MDU3,MIC4)
Experiment(s)
For this entry:
CD44_HUMAN (CD44)
| Species | Homo sapiens |
|---|---|
| Localization | Basolateral plasma membrane |
| Reference |
Chin AR,Yan W,Cao M,Liu X,Wang SE (2018) Polarized Secretion of Extracellular Vesicles by Mammary Epithelia., J Mammary Gland Biol Neoplasia, 23, 165-176. [PubMed] [DOI] |
| Evidence level | Large-scale proteomics |
| Organ | Mammary gland |
| Cell | MCF10A cells (acinar cells) |
| Notes | Detected in the polarized exosome fraction |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
| Start | End | Localisation |
|---|---|---|
| 1 | 20 | Signal peptide |
| 21 | 649 | Extracellular |
| 650 | 670 | Membrane |
| 671 | 742 | Cytoplasmic |
Phosphorylation
| Position | Resource |
|---|---|
| 45 | 41211194 |
| 58 | 41211198 |
| 62 | 3181019 |
| 163 | 23091966 |
| 171 | 23091963 |
| 179 | 40721380 |
| 182 | 40721384 |
| 183 | 27908961 |
| 184 | 54413553 |
| 222 | 22833036 |
| 311 | 55370878 |
| 412 | 477595 |
| 420 | 34368100 |
| 572 | 23091969 |
| 587 | 56568316 |
| 672 | 455524 |
| 686 | 470222 |
| 697 | 465669 |
| 704 | 465561 |
| 706 | 450988 |
| 717 | 33585938 |
| 718 | 4148998 |
| 720 | 3177661 |
| 726 | 15418421 |
Glycosylation
Family and domain data
| Database | Domain/Family name |
|---|---|
| InterPro | C-type_lectin-like/link_sf |
| InterPro | CD44_antigen |
| InterPro | CD44_antigen-like |
| InterPro | CTDL_fold |
| InterPro | Link_dom |
| Pfam | Xlink |
Interactions
| With (links to EBI) | #Exp | PubMed links |
|---|---|---|
| MET_HUMAN | 3 | 22897854 |
| XCT_HUMAN | 4 | 21397861 |
| WASL_HUMAN | 2 | 17092940 |
| HGF_HUMAN | 4 | 22897854 |
| HG2A_HUMAN | 9 | 29190904 |
| PDPK1_HUMAN | 2 | 31980649 |
| OSTP_HUMAN | 4 | 20549562 , 20146103 |
| IPAB_SHIFL | 4 | 11207560 |
| KPCI_HUMAN | 2 | 31980649 |
Protein can be found in apical membrane,
Protein can be found in basal membrane,
Protein can be found both membranes,
Localisation is unknown.