Gene name
ATP1A1
Experiment(s)
For this entry:
AT1A1_HUMAN (ATP1A1)
| Species | Homo sapiens |
|---|---|
| Localization | Apical plasma membrane |
| Reference |
Vagin O,Turdikulova S,Sachs G (2005) Recombinant addition of N-glycosylation sites to the basolateral Na,K-ATPase beta1 subunit results in its clustering in caveolae and apical sorting in HGT-1 cells., J Biol Chem, 280, 43159-67. [PubMed] [DOI] |
| Evidence level | Membrane preparation |
| Organ | Stomach |
| Cell | HGT-1 cells (parietal cells) |
| Notes | Endogenous protein detected by selective biotinylation |
AT1A1_HUMAN (ATP1A1)
| Species | Homo sapiens |
|---|---|
| Localization | Basolateral plasma membrane |
| Reference |
Lobato-Álvarez JA,Roldán ML,López-Murillo TD,González-Ramírez R,Bonilla-Delgado J,Shoshani L (2016) The Apical Localization of Na<sup>+</sup>, K<sup>+</sup>-ATPase in Cultured Human Retinal Pigment Epithelial Cells Depends on Expression of the β<sub>2</sub> Subunit., Front Physiol, 7, 450. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Retina |
| Cell | ARPE-19 cells (pigment epithel cells) |
| Notes |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
| Start | End | Localisation |
|---|---|---|
| 1 | 98 | Cytoplasmic |
| 99 | 116 | Membrane |
| 117 | 128 | Extracellular |
| 129 | 146 | Membrane |
| 147 | 294 | Cytoplasmic |
| 295 | 312 | Membrane |
| 313 | 320 | Extracellular |
| 321 | 339 | Membrane |
| 340 | 776 | Cytoplasmic |
| 777 | 795 | Membrane |
| 796 | 801 | Extracellular |
| 802 | 820 | Membrane |
| 821 | 850 | Cytoplasmic |
| 851 | 868 | Membrane |
| 869 | 919 | Extracellular |
| 920 | 937 | Membrane |
| 938 | 953 | Cytoplasmic |
| 954 | 971 | Membrane |
| 972 | 987 | Extracellular |
| 988 | 1005 | Membrane |
| 1006 | 1023 | Cytoplasmic |
Phosphorylation
| Position | Resource |
|---|---|
| 10 | 452054 |
| 16 | 449086 |
| 47 | 455248 |
| 55 | 461949 |
| 60 | 25283768 |
| 81 | 15719134 |
| 85 | 55369651 |
| 86 | 15719131 |
| 149 | 54363508 |
| 207 | 15719119 |
| 216 | 15417963 |
| 217 | 486205 |
| 222 | 3143910 |
| 226 | 3147483 |
| 228 | 486108 |
| 246 | 12440988 |
| 253 | 38483876 |
| 260 | 454981 |
| 261 | 15402303 |
| 265 | 23084866 |
| 369 | 2025077 |
| 378 | 2025097 |
| 407 | 4765869 |
| 452 | 485853 |
| 466 | 36123469 |
| 484 | 10273345 |
| 488 | 34668654 |
| 498 | 27444426 |
| 499 | 27721247 |
| 520 | 27444422 |
| 542 | 458467 |
| 617 | 25731172 |
| 623 | 27723202 |
| 640 | 2049793 |
| 653 | 4148938 |
| 684 | 2150929 |
| 686 | 23084869 |
| 722 | 4765893 |
| 902 | 55369655 |
| 943 | 451649 |
Family and domain data
| Database | Domain/Family name |
|---|---|
| InterPro | ATPase_P-typ_cation-transptr_C |
| InterPro | ATPase_P-typ_cation-transptr_N |
| InterPro | ATPase_P-typ_cyto_dom_N |
| InterPro | ATPase_P-typ_P_site |
| InterPro | ATPase_P-typ_TM_dom_sf |
| InterPro | ATPase_P-typ_transduc_dom_A_sf |
| InterPro | HAD-like_sf |
| InterPro | HAD_sf |
| InterPro | P-type_ATPase_IIC |
| InterPro | P_typ_ATPase |
| Pfam | Cation_ATPase_C |
| Pfam | Cation_ATPase_N |
Interactions
| With (links to EBI) | #Exp | PubMed links |
|---|---|---|
| ERBB2_HUMAN | 2 | 26496610 , 24189400 |
| LRRK2_HUMAN | 2 | 31046837 |
| VDAC1_HUMAN | 2 | 29128334 |
| SDHA_HUMAN | 2 | 29128334 |
| R1AB_SARS2 | 7 | unassigned2359 |
| CD81_HUMAN | 3 | 30024968 |
| AT1B1_HUMAN | 2 | 30021884 , 25012180 |
| SODC_HUMAN | 2 | 29128334 |
| ODPA_HUMAN | 2 | 29128334 |
| COX15_HUMAN | 2 | 29128334 |
| TECT3_HUMAN | 2 | 26638075 |
| Q77M19_MEASW | 2 | 21911578 |
| TMM17_HUMAN | 2 | 26638075 |
Protein can be found in apical membrane,
Protein can be found in basal membrane,
Protein can be found both membranes,
Localisation is unknown.