Gene name
ATP1A1
Experiment(s)
For this entry:
AT1A1_CANLF (ATP1A1)
| Species | Canis lupus familiaris |
|---|---|
| Localization | Basolateral plasma membrane |
| Reference |
Vagin O,Turdikulova S,Sachs G (2005) Recombinant addition of N-glycosylation sites to the basolateral Na,K-ATPase beta1 subunit results in its clustering in caveolae and apical sorting in HGT-1 cells., J Biol Chem, 280, 43159-67. [PubMed] [DOI] |
| Evidence level | Membrane preparation |
| Organ | Kidney |
| Cell | MDCK cells (distal tubule) |
| Notes | Endogenous protein detected by selective biotinylation |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
| Start | End | Localisation |
|---|---|---|
| 1 | 96 | Cytoplasmic |
| 97 | 114 | Membrane |
| 115 | 126 | Extracellular |
| 127 | 144 | Membrane |
| 145 | 292 | Cytoplasmic |
| 293 | 310 | Membrane |
| 311 | 318 | Extracellular |
| 319 | 337 | Membrane |
| 338 | 774 | Cytoplasmic |
| 775 | 793 | Membrane |
| 794 | 799 | Extracellular |
| 800 | 818 | Membrane |
| 819 | 848 | Cytoplasmic |
| 849 | 866 | Membrane |
| 867 | 917 | Extracellular |
| 918 | 935 | Membrane |
| 936 | 951 | Cytoplasmic |
| 952 | 969 | Membrane |
| 970 | 985 | Extracellular |
| 986 | 1003 | Membrane |
| 1004 | 1021 | Cytoplasmic |
Family and domain data
| Database | Domain/Family name |
|---|---|
| InterPro | ATPase_P-typ_cation-transptr_C |
| InterPro | ATPase_P-typ_cation-transptr_N |
| InterPro | ATPase_P-typ_cyto_dom_N |
| InterPro | ATPase_P-typ_P_site |
| InterPro | ATPase_P-typ_TM_dom_sf |
| InterPro | ATPase_P-typ_transduc_dom_A_sf |
| InterPro | HAD-like_sf |
| InterPro | HAD_sf |
| InterPro | P-type_ATPase_IIC |
| InterPro | P_typ_ATPase |
| Pfam | Cation_ATPase_C |
| Pfam | Cation_ATPase_N |