Gene name
UMOD
Experiment(s)
For this entry:
UROM_HUMAN (UMOD)
| Species | Homo sapiens |
|---|---|
| Localization | Apical plasma membrane |
| Reference |
Stuiver M,Lainez S,Will C,Terryn S,Günzel D,Debaix H,Sommer K,Kopplin K,Thumfart J,Kampik NB,Querfeld U,Willnow TE,Němec V,Wagner CA,Hoenderop JG,Devuyst O,Knoers NV,Bindels RJ,Meij IC,Müller D (2011) CNNM2, encoding a basolateral protein required for renal Mg2+ handling, is mutated in dominant hypomagnesemia., Am J Hum Genet, 88, 333-43. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Kidney |
| Cell | Henle's loop / TAL cells |
| Notes |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
| Start | End | Localisation |
|---|---|---|
| 1 | 640 | Extracellular |
Phosphorylation
Glycosylation
Family and domain data
| Database | Domain/Family name |
|---|---|
| InterPro | EGF-like_Ca-bd_dom |
| InterPro | EGF-like_dom |
| InterPro | EGF-type_Asp/Asn_hydroxyl_site |
| InterPro | EGF_Ca-bd_CS |
| InterPro | EGF_dom |
| InterPro | Growth_fac_rcpt_cys_sf |
| InterPro | ZP_dom |
| InterPro | ZP_dom_CS |
| Pfam | EGF_3 |
| Pfam | EGF_CA |
| Pfam | Zona_pellucida |