Gene name
Slc9a3 (Nhe3)
Experiment(s)
For this entry:
SL9A3_RAT (Slc9a3)
| Species | Rattus norvegicus |
|---|---|
| Localization | Apical plasma membrane |
| Reference |
Nejsum LN,Praetorius J,Nielsen S (2005) NKCC1 and NHE1 are abundantly expressed in the basolateral plasma membrane of secretory coil cells in rat, mouse, and human sweat glands., Am J Physiol Cell Physiol, 289, C333-40. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Kidney |
| Cell | Proximal tubules |
| Notes |
SL9A3_RAT (Slc9a3)
| Species | Rattus norvegicus |
|---|---|
| Localization | Apical plasma membrane |
| Reference |
Jakab RL,Collaco AM,Ameen NA (2011) Physiological relevance of cell-specific distribution patterns of CFTR, NKCC1, NBCe1, and NHE3 along the crypt-villus axis in the intestine., Am J Physiol Gastrointest Liver Physiol, 300, G82-98. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Small intestine |
| Cell | Enterocytes |
| Notes |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
| Start | End | Localisation |
|---|---|---|
| 1 | 29 | Signal peptide |
| 30 | 50 | Extracellular |
| 51 | 70 | Membrane |
| 71 | 77 | Cytoplasmic |
| 78 | 99 | Membrane |
| 100 | 106 | Extracellular |
| 107 | 127 | Membrane |
| 128 | 136 | Cytoplasmic |
| 137 | 159 | Membrane |
| 160 | 175 | Extracellular |
| 176 | 197 | Membrane |
| 198 | 204 | Cytoplasmic |
| 205 | 224 | Membrane |
| 225 | 247 | Extracellular |
| 248 | 271 | Membrane |
| 272 | 280 | Cytoplasmic |
| 281 | 297 | Membrane |
| 298 | 299 | Extracellular |
| 300 | 316 | Membrane |
| 317 | 337 | Cytoplasmic |
| 338 | 357 | Membrane |
| 358 | 365 | Extracellular |
| 366 | 387 | Membrane |
| 388 | 403 | Cytoplasmic |
| 404 | 423 | Membrane |
| 424 | 432 | Extracellular |
| 433 | 453 | Membrane |
| 454 | 831 | Cytoplasmic |
Eukaryotic Linear Motif (ELM)
| Start | End | Sequence | Motif |
|---|---|---|---|
| 747 | 755 | AGIDNPVFS | LIG_PTB_Apo_2 |
Phosphorylation
Family and domain data
| Database | Domain/Family name |
|---|---|
| InterPro | Cation/H_exchanger |
| InterPro | Cation/H_exchanger_CPA1 |
| InterPro | Na/H_exchanger_3/5 |
| InterPro | NaH_exchanger |
| Pfam | Na_H_Exchanger |