Gene name
Slc9a3 (Nhe3)
Experiment(s)
For this entry:
SL9A3_MOUSE (Slc9a3)
| Species | Mus musculus |
|---|---|
| Localization | Apical plasma membrane |
| Reference |
Petrovic S,Barone S,Wang Z,McDonough AA,Amlal H,Soleimani M (2008) Slc26a6 (PAT1) deletion downregulates the apical Na+/H+ exchanger in the straight segment of the proximal tubule., Am J Nephrol, 28, 330-8. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Kidney |
| Cell | Proximal tubules |
| Notes |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
| Start | End | Localisation |
|---|---|---|
| 1 | 27 | Signal peptide |
| 28 | 50 | Extracellular |
| 51 | 69 | Membrane |
| 70 | 75 | Cytoplasmic |
| 76 | 97 | Membrane |
| 98 | 104 | Extracellular |
| 105 | 125 | Membrane |
| 126 | 134 | Cytoplasmic |
| 135 | 161 | Membrane |
| 162 | 170 | Extracellular |
| 171 | 195 | Membrane |
| 196 | 202 | Cytoplasmic |
| 203 | 222 | Membrane |
| 223 | 245 | Extracellular |
| 246 | 269 | Membrane |
| 270 | 278 | Cytoplasmic |
| 279 | 295 | Membrane |
| 296 | 297 | Extracellular |
| 298 | 314 | Membrane |
| 315 | 335 | Cytoplasmic |
| 336 | 355 | Membrane |
| 356 | 362 | Extracellular |
| 363 | 383 | Membrane |
| 384 | 402 | Cytoplasmic |
| 403 | 421 | Membrane |
| 422 | 430 | Extracellular |
| 431 | 451 | Membrane |
| 452 | 829 | Cytoplasmic |
Eukaryotic Linear Motif (ELM)
| Start | End | Sequence | Motif |
|---|---|---|---|
| 745 | 753 | AGIDNPVFS | LIG_PTB_Apo_2 |
Phosphorylation
Family and domain data
| Database | Domain/Family name |
|---|---|
| InterPro | Cation/H_exchanger |
| InterPro | Cation/H_exchanger_CPA1 |
| InterPro | Na/H_exchanger_3/5 |
| InterPro | NaH_exchanger |
| InterPro | Reg_factor_effector_dom_sf |
| Pfam | Na_H_Exchanger |