Gene name
Slc9a3 (Nhe3)
Experiment(s)
For this entry:
SL9A3_RABIT (Slc9a3)
| Species | Oryctolagus cuniculus |
|---|---|
| Localization | Apical plasma membrane |
| Reference |
Cha B,Kenworthy A,Murtazina R,Donowitz M (2004) The lateral mobility of NHE3 on the apical membrane of renal epithelial OK cells is limited by the PDZ domain proteins NHERF1/2, but is dependent on an intact actin cytoskeleton as determined by FRAP., J Cell Sci, 117, 3353-65. [PubMed] [DOI] |
| Evidence level | Fluorescent tagging |
| Organ | Kidney |
| Cell | OK cells (proximal tubule) |
| Notes |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
| Start | End | Localisation |
|---|---|---|
| 1 | 30 | Signal peptide |
| 31 | 54 | Extracellular |
| 55 | 71 | Membrane |
| 72 | 80 | Cytoplasmic |
| 81 | 101 | Membrane |
| 102 | 110 | Extracellular |
| 111 | 130 | Membrane |
| 131 | 139 | Cytoplasmic |
| 140 | 161 | Membrane |
| 162 | 180 | Extracellular |
| 181 | 199 | Membrane |
| 200 | 206 | Cytoplasmic |
| 207 | 227 | Membrane |
| 228 | 250 | Extracellular |
| 251 | 272 | Membrane |
| 273 | 282 | Cytoplasmic |
| 283 | 299 | Membrane |
| 300 | 301 | Extracellular |
| 302 | 318 | Membrane |
| 319 | 339 | Cytoplasmic |
| 340 | 358 | Membrane |
| 359 | 367 | Extracellular |
| 368 | 389 | Membrane |
| 390 | 405 | Cytoplasmic |
| 406 | 425 | Membrane |
| 426 | 434 | Extracellular |
| 435 | 455 | Membrane |
| 456 | 832 | Cytoplasmic |
Eukaryotic Linear Motif (ELM)
| Start | End | Sequence | Motif |
|---|---|---|---|
| 753 | 761 | AGIDNPVFS | LIG_PTB_Apo_2 |
Phosphorylation
Family and domain data
| Database | Domain/Family name |
|---|---|
| InterPro | Cation/H_exchanger |
| InterPro | Cation/H_exchanger_CPA1 |
| InterPro | Na/H_exchanger_3/5 |
| InterPro | NaH_exchanger |
| Pfam | Na_H_Exchanger |