Gene name
Slc4a4 (Nbc,Nbc1,Nbce1,Rnbc1)
Experiment(s)
For this entry:
S4A4_RAT (Slc4a4)
| Species | Rattus norvegicus |
|---|---|
| Localization | Basolateral plasma membrane |
| Reference |
Jakab RL,Collaco AM,Ameen NA (2011) Physiological relevance of cell-specific distribution patterns of CFTR, NKCC1, NBCe1, and NHE3 along the crypt-villus axis in the intestine., Am J Physiol Gastrointest Liver Physiol, 300, G82-98. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Small intestine |
| Cell | Enterocytes |
| Notes |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
| Start | End | Localisation |
|---|---|---|
| 1 | 471 | Cytoplasmic |
| 472 | 487 | Membrane |
| 488 | 503 | Extracellular |
| 504 | 519 | Membrane |
| 520 | 521 | Cytoplasmic |
| 522 | 537 | Membrane |
| 538 | 553 | Extracellular |
| 554 | 569 | Membrane |
| 570 | 587 | Cytoplasmic |
| 588 | 605 | Membrane |
| 606 | 689 | Extracellular |
| 690 | 710 | Membrane |
| 711 | 726 | Cytoplasmic |
| 727 | 742 | Membrane |
| 743 | 779 | Extracellular |
| 780 | 800 | Membrane |
| 801 | 821 | Cytoplasmic |
| 822 | 837 | Membrane |
| 838 | 839 | Extracellular |
| 840 | 855 | Membrane |
| 856 | 877 | Cytoplasmic |
| 878 | 893 | Membrane |
| 894 | 901 | Extracellular |
| 902 | 917 | Membrane |
| 918 | 958 | Cytoplasmic |
| 959 | 977 | Re-entrant loop |
| 978 | 1079 | Cytoplasmic |
Phosphorylation
Glycosylation
Family and domain data
| Database | Domain/Family name |
|---|---|
| InterPro | Band3_cytoplasmic_dom |
| InterPro | HCO3_transpt_C |
| InterPro | HCO3_transpt_euk |
| InterPro | Na/HCO3_transpt |
| InterPro | PTrfase/Anion_transptr |
| Pfam | Band_3_cyto |
| Pfam | HCO3_cotransp |