Gene name
SLC22A6 (Oat1,PAHT,Nkt)
Experiment(s)
For this entry:
S22A6_RAT (SLC22A6)
| Species | Rattus norvegicus |
|---|---|
| Localization | Basolateral plasma membrane |
| Reference |
Ljubojevic M,Herak-Kramberger CM,Hagos Y,Bahn A,Endou H,Burckhardt G,Sabolic I (2004) Rat renal cortical OAT1 and OAT3 exhibit gender differences determined by both androgen stimulation and estrogen inhibition., Am J Physiol Renal Physiol, 287, F124-38. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Kidney |
| Cell | Proximal tubules |
| Notes |
S22A6_RAT (SLC22A6)
| Species | Rattus norvegicus |
|---|---|
| Localization | Basolateral plasma membrane |
| Reference |
Kojima R,Sekine T,Kawachi M,Cha SH,Suzuki Y,Endou H (2002) Immunolocalization of multispecific organic anion transporters, OAT1, OAT2, and OAT3, in rat kidney., J Am Soc Nephrol, 13, 848-57. [PubMed] |
| Evidence level | Antibody staining |
| Organ | Kidney |
| Cell | Proximal tubules |
| Notes | Only expressed in the proximal tubule S2 and S3 segments. Not elsewhere in kidney. |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
| Start | End | Localisation |
|---|---|---|
| 1 | 12 | Cytoplasmic |
| 13 | 33 | Membrane |
| 34 | 135 | Extracellular |
| 136 | 156 | Membrane |
| 157 | 163 | Cytoplasmic |
| 164 | 183 | Membrane |
| 184 | 189 | Extracellular |
| 190 | 210 | Membrane |
| 211 | 220 | Cytoplasmic |
| 221 | 241 | Membrane |
| 242 | 248 | Extracellular |
| 249 | 268 | Membrane |
| 269 | 337 | Cytoplasmic |
| 338 | 357 | Membrane |
| 358 | 367 | Extracellular |
| 368 | 389 | Membrane |
| 390 | 396 | Cytoplasmic |
| 397 | 417 | Membrane |
| 418 | 424 | Extracellular |
| 425 | 445 | Membrane |
| 446 | 455 | Cytoplasmic |
| 456 | 476 | Membrane |
| 477 | 483 | Extracellular |
| 484 | 504 | Membrane |
| 505 | 551 | Cytoplasmic |
Family and domain data
| Database | Domain/Family name |
|---|---|
| InterPro | MFS_dom |
| InterPro | MFS_sugar_transport-like |
| InterPro | MFS_trans_sf |
| InterPro | Orgcat_transp/SVOP |
| Pfam | Sugar_tr |