Gene name
SLC22A6 (Oat1,PAHT,Nkt)
Experiment(s)
For this entry:
S22A6_HUMAN (SLC22A6)
| Species | Homo sapiens |
|---|---|
| Localization | Basolateral plasma membrane |
| Reference |
Ekaratanawong S,Anzai N,Jutabha P,Miyazaki H,Noshiro R,Takeda M,Kanai Y,Sophasan S,Endou H (2004) Human organic anion transporter 4 is a renal apical organic anion/dicarboxylate exchanger in the proximal tubules., J Pharmacol Sci, 94, 297-304. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Kidney |
| Cell | Proximal tubules |
| Notes |
S22A6_HUMAN (SLC22A6)
| Species | Homo sapiens |
|---|---|
| Localization | Basolateral plasma membrane |
| Reference |
Motohashi H,Nakao Y,Masuda S,Katsura T,Kamba T,Ogawa O,Inui K (2013) Precise comparison of protein localization among OCT, OAT, and MATE in human kidney., J Pharm Sci, 102, 3302-8. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Kidney |
| Cell | Proximal tubules |
| Notes |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
| Start | End | Localisation |
|---|---|---|
| 1 | 17 | Cytoplasmic |
| 18 | 37 | Membrane |
| 38 | 135 | Extracellular |
| 136 | 156 | Membrane |
| 157 | 163 | Cytoplasmic |
| 164 | 183 | Membrane |
| 184 | 190 | Extracellular |
| 191 | 211 | Membrane |
| 212 | 220 | Cytoplasmic |
| 221 | 241 | Membrane |
| 242 | 248 | Extracellular |
| 249 | 268 | Membrane |
| 269 | 337 | Cytoplasmic |
| 338 | 357 | Membrane |
| 358 | 367 | Extracellular |
| 368 | 388 | Membrane |
| 389 | 395 | Cytoplasmic |
| 396 | 416 | Membrane |
| 417 | 424 | Extracellular |
| 425 | 445 | Membrane |
| 446 | 455 | Cytoplasmic |
| 456 | 476 | Membrane |
| 477 | 483 | Extracellular |
| 484 | 504 | Membrane |
| 505 | 563 | Cytoplasmic |
Phosphorylation
Glycosylation
Family and domain data
| Database | Domain/Family name |
|---|---|
| InterPro | MFS_dom |
| InterPro | MFS_sugar_transport-like |
| InterPro | MFS_trans_sf |
| InterPro | Orgcat_transp/SVOP |
| Pfam | Sugar_tr |
Interactions
| With (links to EBI) | #Exp | PubMed links |
|---|---|---|
| APBP2_HUMAN | 3 | 19060904 , 16189514 |
Protein can be found in apical membrane,
Protein can be found in basal membrane,
Protein can be found both membranes,
Localisation is unknown.