Gene name
P4HB (PDIA1,ERBA2L,PDI,PO4DB)
Experiment(s)
For this entry:
PDIA1_HUMAN (P4HB)
| Species | Homo sapiens |
|---|---|
| Localization | Non polar membrane |
| Reference |
Touzelet O,Broadbent L,Armstrong SD,Aljabr W,Cloutman-Green E,Power UF,Hiscox JA (2020) The Secretome Profiling of a Pediatric Airway Epithelium Infected with hRSV Identified Aberrant Apical/Basolateral Trafficking and Novel Immune Modulating (CXCL6, CXCL16, CSF3) and Antiviral (CEACAM1) Proteins., Mol Cell Proteomics, 19, 793-807. [PubMed] [DOI] |
| Evidence level | Large-scale proteomics |
| Organ | Lung |
| Cell | Airway epithel cells |
| Notes |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
| Start | End | Localisation |
|---|---|---|
| 1 | 508 | Extracellular |
Phosphorylation
Glycosylation
| Position | Site resource | Glycan resource | PubMed link(s) |
|---|---|---|---|
| 85 | O-GlycoProteomDB | ||
| 117 | PolarProtDb |
![WURCS=2.0/1,1,0/[axxxxh-1x_1-5_2*NCC/3=O]/1/](data:image/png;base64,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)
|
29296958 |
| 117 | O-GlycoProteomDB | ||
| 187 | O-GlycoProteomDB | ||
| 194 | O-GlycoProteomDB | ||
| 221 | O-GlycoProteomDB | ||
| 241 | O-GlycoProteomDB | ||
| 428 | O-GlycoProteomDB | ||
| 442 | PhosphoSitePlus |
![WURCS=2.0/1,1,0/[a2112h-1x_1-5_2*NCC/3=O]/1/](data:image/png;base64,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)
|
|
| 442 | dbPTM | 29155159 | |
| 462 | O-GlycoProteomDB |
Family and domain data
| Database | Domain/Family name |
|---|---|
| InterPro | Disulphide_isomerase |
| InterPro | Prot_disulphide_isomerase |
| InterPro | Thioredoxin-like_sf |
| InterPro | Thioredoxin_CS |
| InterPro | Thioredoxin_domain |
| Pfam | Thioredoxin |
Interactions
Protein can be found in apical membrane,
Protein can be found in basal membrane,
Protein can be found both membranes,
Localisation is unknown.