Gene name
Pdia4 (Erp70,ERP72,Cabp2)
Experiment(s)
For this entry:
PDIA4_HUMAN (Pdia4)
| Species | Homo sapiens |
|---|---|
| Localization | Non polar membrane |
| Reference |
Touzelet O,Broadbent L,Armstrong SD,Aljabr W,Cloutman-Green E,Power UF,Hiscox JA (2020) The Secretome Profiling of a Pediatric Airway Epithelium Infected with hRSV Identified Aberrant Apical/Basolateral Trafficking and Novel Immune Modulating (CXCL6, CXCL16, CSF3) and Antiviral (CEACAM1) Proteins., Mol Cell Proteomics, 19, 793-807. [PubMed] [DOI] |
| Evidence level | Large-scale proteomics |
| Organ | Lung |
| Cell | Airway epithel cells |
| Notes |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
| Start | End | Localisation |
|---|---|---|
| 1 | 645 | Extracellular |
Phosphorylation
| Position | Resource |
|---|---|
| 101 | 5593417 |
| 124 | 31881342 |
| 130 | 31873809 |
| 137 | 55370559 |
| 168 | 31854367 |
| 173 | 55370563 |
| 227 | 54414992 |
| 238 | 23130611 |
| 241 | 55370567 |
| 252 | 38485664 |
| 254 | 27460169 |
| 264 | 38485816 |
| 266 | 23130614 |
| 273 | 15177608 |
| 278 | 15177611 |
| 287 | 55370571 |
| 320 | 55370575 |
| 323 | 55370579 |
| 351 | 31878317 |
| 367 | 3548091 |
| 379 | 34362451 |
| 380 | 34362454 |
| 383 | 34362457 |
| 392 | 40407803 |
| 403 | 50786228 |
| 409 | 50786240 |
| 410 | 50786236 |
| 448 | 55370583 |
| 449 | 55370587 |
| 458 | 55370591 |
| 468 | 55370595 |
| 470 | 40512984 |
| 495 | 55370599 |
| 516 | 34362193 |
| 551 | 15405171 |
| 565 | 55370603 |
| 567 | 50786232 |
| 586 | 25280282 |
| 592 | 31870671 |
| 604 | 55370607 |
| 608 | 31075304 |
Glycosylation
| Position | Site resource | Glycan resource | PubMed link(s) |
|---|---|---|---|
| 123 | O-GlycoProteomDB | ||
| 130 | O-GlycoProteomDB | ||
| 135 | O-GlycoProteomDB | ||
| 139 | O-GlycoProteomDB | ||
| 238 | O-GlycoProteomDB | ||
| 250 | O-GlycoProteomDB | ||
| 341 | O-GlycoProteomDB | ||
| 503 | PhosphoSitePlus |
![WURCS=2.0/1,1,0/[a2112h-1x_1-5_2*NCC/3=O]/1/](data:image/png;base64,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)
|
|
| 503 | dbPTM | 55829001 | |
| 503 | O-GlycoProteomDB |
Family and domain data
| Database | Domain/Family name |
|---|---|
| InterPro | Disulphide_isomerase |
| InterPro | PDIA4_PDI_b |
| InterPro | Prot_disulphide_isomerase |
| InterPro | Protein_diS-isomerase_A4 |
| InterPro | Thioredoxin-like_sf |
| InterPro | Thioredoxin_CS |
| InterPro | Thioredoxin_domain |
| Pfam | Thioredoxin |
Interactions
| With (links to EBI) | #Exp | PubMed links |
|---|---|---|
| KR411_HUMAN | 3 | 32296183 |
| KR108_HUMAN | 3 | 32296183 |
| CFTR_HUMAN | 8 | 29924966 |
| POL_HV1B1 | 2 | 22190034 |
| PPIB_HUMAN | 5 | 30021884 , 22665516 |
| MATN3_HUMAN | 6 | 23956175 , 16287128 |
| COMP_HUMAN | 2 | 23956175 |
| TECT2_HUMAN | 2 | 26638075 |
| SNF5_HUMAN | 2 | 30108113 |
| TECT3_HUMAN | 2 | 26638075 |
| LAMP1_HUMAN | 2 | 29568061 |
| SODC_HUMAN | 2 | 29128334 |
| NGAL_HUMAN | 3 | 32296183 |
| NRAM_I34A1 | 2 | 28169297 |
| KR121_HUMAN | 3 | 32296183 |
| TECT1_HUMAN | 2 | 26638075 |
| CREL2_MOUSE | 2 | 23956175 |
| PLRKT_HUMAN | 2 | 29568061 |
| LRRK2_HUMAN | 2 | 31046837 |
| Q76353_9HIV1 | 3 | 22190034 |
Protein can be found in apical membrane,
Protein can be found in basal membrane,
Protein can be found both membranes,
Localisation is unknown.