Gene name
NRG1 (GGF,HGL,HRGA,NDF,SMDF)
Experiment(s)
For this entry:
NRG1_HUMAN (NRG1)
| Species | Homo sapiens |
|---|---|
| Localization | Apical plasma membrane |
| Reference |
Vermeer PD,Einwalter LA,Moninger TO,Rokhlina T,Kern JA,Zabner J,Welsh MJ (2003) Segregation of receptor and ligand regulates activation of epithelial growth factor receptor., Nature, 422, 322-6. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Lung |
| Cell | Airway epithel cells |
| Notes |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
| Start | End | Localisation |
|---|---|---|
| 1 | 242 | Extracellular |
| 243 | 265 | Membrane |
| 266 | 640 | Cytoplasmic |
Eukaryotic Linear Motif (ELM)
| Start | End | Sequence | Motif |
|---|---|---|---|
| 387 | 391 | GPRGR | TRG_ER_diArg_1 |
| 483 | 487 | PPRLR | TRG_ER_diArg_1 |
Phosphorylation
Glycosylation
| Position | Site resource | Glycan resource | PubMed link(s) |
|---|---|---|---|
| 30 | PolarProtDb |
![WURCS=2.0/2,2,1/[axxxxh-1x_1-5_2*NCC/3=O][axxxxh-1x_1-5]/1-2/a?-b1](data:image/png;base64,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)
|
29296958 |
| 30 | O-GlycoProteomDB | ||
| 120 | N-GlycoSiteAtlas | ||
| 126 | N-GlycoSiteAtlas | ||
| 137 | O-GlycoProteomDB | ||
| 142 | O-GlycoProteomDB | ||
| 143 | O-GlycoProteomDB |
Family and domain data
| Database | Domain/Family name |
|---|---|
| InterPro | EGF-like_dom |
| InterPro | Ig-like_dom |
| InterPro | Ig-like_dom_sf |
| InterPro | Ig-like_fold |
| InterPro | Ig_I-set |
| InterPro | Ig_sub |
| InterPro | Ig_sub2 |
| InterPro | Neuregulin |
| InterPro | Neuregulin_C |
| InterPro | NRG1 |
| Pfam | EGF |
| Pfam | I-set |
| Pfam | Neuregulin |
Interactions
| With (links to EBI) | #Exp | PubMed links |
|---|---|---|
| EGFR_HUMAN | 2 | 24658140 , 31980649 |
| ERBB3_HUMAN | 7 | 7592681 , unassigned1913 , 28988771 |
| ERBB2_HUMAN | 2 | 7592681 |
Protein can be found in apical membrane,
Protein can be found in basal membrane,
Protein can be found both membranes,
Localisation is unknown.