PolarProtDb

Gene name

LTBP4

Experiment(s)

For this entry:

LTBP4_HUMAN (LTBP4)

Species	Homo sapiens
Localization	Basolateral plasma membrane
Reference	Touzelet O,Broadbent L,Armstrong SD,Aljabr W,Cloutman-Green E,Power UF,Hiscox JA (2020) The Secretome Profiling of a Pediatric Airway Epithelium Infected with hRSV Identified Aberrant Apical/Basolateral Trafficking and Novel Immune Modulating (CXCL6, CXCL16, CSF3) and Antiviral (CEACAM1) Proteins., Mol Cell Proteomics, 19, 793-807. [PubMed] [DOI]
Evidence level	Large-scale proteomics
Organ	Lung
Cell	Airway epithel cells
Notes	Only mock-transfected cells were considered

For ortholog entries:

Alignment and sequence features

Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).

CCTOP topology prediction

Start	End	Localisation
1	1624	Extracellular

Phosphorylation

Position	Resource
96	34500554
98	22350396
280	463388
281	25299257
284	25299261
288	463389
300	27452431
579	27452435
833	23123458
1152	41452830
1170	34427452
1442	3974089
1449	3974094
1452	3974099
1483	34348885
1486	34348888
1496	34348891

Glycosylation

Position	Site resource	Glycan resource	PubMed link(s)
31	UniCarbKB	$WURCS=2.0/2,4,3/[uxxxxh_2*NCC/3=O][uxxxxh]/1-1-2-2/a?\|b?\|c?\|d?}-{a?\|b?\|c?\|d?_a?\|b?\|c?\|d?}-{a?\|b?\|c?\|d?_a?\|b?\|c?\|d?}-{a?\|b?\|c?\|d?$	30459171
31	UniCarbKB	$WURCS=2.0/2,2,1/[uxxxxh_2*NCC/3=O][uxxxxh]/1-2/a?\|b?}-{a?\|b?$	30459171
33	UniCarbKB	$WURCS=2.0/2,2,1/[uxxxxh_2*NCC/3=O][uxxxxh]/1-2/a?\|b?}-{a?\|b?$	30459171
35	UniCarbKB	$WURCS=2.0/2,2,1/[uxxxxh_2*NCC/3=O][uxxxxh]/1-2/a?\|b?}-{a?\|b?$	30459171
45	UniCarbKB		30459171
200	O-GlycoProteomDB
203	O-GlycoProteomDB
221	O-GlycoProteomDB
231	UniCarbKB		30459171
231	O-GlycoProteomDB
241	O-GlycoProteomDB
268	O-GlycoProteomDB
268	UniCarbKB		30459171
273	O-GlycoProteomDB
338	O-GlycoProteomDB
346	PhosphoSitePlus
346	dbPTM		55832119
346	O-GlycoProteomDB
352	N-GlycoSiteAtlas		23090970
468	PhosphoSitePlus
468	dbPTM		55824887
468	O-GlycoProteomDB
476	PhosphoSitePlus
476	dbPTM		55832161
476	O-GlycoProteomDB
487	O-GlycoProteomDB
493	PolarProtDb	$WURCS=2.0/3,3,2/[AUd21122h_5NCC/3=O][uxxxxh_2NCC/3=O][uxxxxh]/1-2-3/a?\|b?\|c?}-{a?\|b?\|c?_a?\|b?\|c?}-{a?\|b?\|c?$	27695962
493	O-GlycoProteomDB
497	UniCarbKB		30459171
497	UniCarbKB	$WURCS=2.0/2,2,1/[uxxxxh_2*NCC/3=O][uxxxxh]/1-2/a?\|b?}-{a?\|b?$	30459171
497	PolarProtDb		29296958
497	O-GlycoProteomDB
498	O-GlycoProteomDB
501	UniCarbKB	$WURCS=2.0/2,2,1/[uxxxxh_2*NCC/3=O][uxxxxh]/1-2/a?\|b?}-{a?\|b?$	30459171
501	O-GlycoProteomDB
507	O-GlycoProteomDB
530	UniCarbKB	$WURCS=2.0/2,2,1/[uxxxxh_2*NCC/3=O][uxxxxh]/1-2/a?\|b?}-{a?\|b?$	30459171
535	UniCarbKB	$WURCS=2.0/2,2,1/[uxxxxh_2*NCC/3=O][uxxxxh]/1-2/a?\|b?}-{a?\|b?$	30459171
542	UniCarbKB	$WURCS=2.0/2,2,1/[uxxxxh_2*NCC/3=O][uxxxxh]/1-2/a?\|b?}-{a?\|b?$	30459171
1200	N-GlycoSiteAtlas		24324730 , 24495048
1322	O-GlycoProteomDB
1339	N-GlycoSiteAtlas
1486	UniCarbKB	$WURCS=2.0/2,2,1/[uxxxxh_2*NCC/3=O][uxxxxh]/1-2/a?\|b?}-{a?\|b?$	30459171

Family and domain data

Database	Domain/Family name
InterPro	EGF-like_Ca-bd_dom
InterPro	EGF-like_CS
InterPro	EGF-like_dom
InterPro	EGF-type_Asp/Asn_hydroxyl_site
InterPro	EGF_Ca-bd_CS
InterPro	Growth_fac_rcpt_cys_sf
InterPro	TB_dom
InterPro	TB_dom_sf
Pfam	EGF_CA
Pfam	hEGF
Pfam	TB

Interactions

With (links to EBI)	#Exp	PubMed links
ATX7_HUMAN	2	21078624
GFI1B_HUMAN	2	16713569
ATN1_HUMAN	2	16713569
CAC1A_HUMAN	2	21078624

Protein can be found in apical membrane, Protein can be found in basal membrane, Protein can be found both membranes, Localisation is unknown.