Gene name
LDLR
Experiment(s)
For this entry:
LDLR_HUMAN (LDLR)
Species | Homo sapiens |
---|---|
Localization | Apical plasma membrane |
Reference |
Fölsch H,Ohno H,Bonifacino JS,Mellman I (1999) A novel clathrin adaptor complex mediates basolateral targeting in polarized epithelial cells., Cell, 99, 189-98. [PubMed] [DOI] |
Evidence level | Antibody staining |
Organ | Kidney |
Cell | LLC-PK1 cells (proximal tubule) |
Notes | Source of vectors were not described properly. Expression of AP-1B causes basolateral sorting |
LDLR_HUMAN (LDLR)
Species | Homo sapiens |
---|---|
Localization | Apical plasma membrane |
Reference |
Sugimoto H,Sugahara M,Fölsch H,Koide Y,Nakatsu F,Tanaka N,Nishimura T,Furukawa M,Mullins C,Nakamura N,Mellman I,Ohno H (2002) Differential recognition of tyrosine-based basolateral signals by AP-1B subunit mu1B in polarized epithelial cells., Mol Biol Cell, 13, 2374-82. [PubMed] [DOI] |
Evidence level | Antibody staining |
Organ | Kidney |
Cell | LLC-PK1 cells (proximal tubule) |
Notes | Expression of AP-1B causes basolateral sorting |
LDLR_HUMAN (LDLR)
Species | Homo sapiens |
---|---|
Localization | Basolateral plasma membrane |
Reference |
Fölsch H,Ohno H,Bonifacino JS,Mellman I (1999) A novel clathrin adaptor complex mediates basolateral targeting in polarized epithelial cells., Cell, 99, 189-98. [PubMed] [DOI] |
Evidence level | Antibody staining |
Organ | Kidney |
Cell | MDCK cells (distal tubule) |
Notes | Source of vectors were not described |
LDLR_HUMAN (LDLR)
Species | Homo sapiens |
---|---|
Localization | Basolateral plasma membrane |
Reference |
Kang RS,Fölsch H (2011) ARH cooperates with AP-1B in the exocytosis of LDLR in polarized epithelial cells., J Cell Biol, 193, 51-60. [PubMed] [DOI] |
Evidence level | Antibody staining |
Organ | Lung |
Cell | Airway epithel cells |
Notes | Source of vectors were not described |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
Start | End | Localisation |
---|---|---|
1 | 21 | Signal peptide |
22 | 788 | Extracellular |
789 | 809 | Membrane |
810 | 860 | Cytoplasmic |
Phosphorylation
Glycosylation
Family and domain data
Database | Domain/Family name |
---|---|
InterPro | 6-blade_b-propeller_TolB-like |
InterPro | EGF-like_Ca-bd_dom |
InterPro | EGF-like_dom |
InterPro | EGF-type_Asp/Asn_hydroxyl_site |
InterPro | EGF_Ca-bd_CS |
InterPro | Growth_fac_rcpt_cys_sf |
InterPro | LDL_receptor-like_sf |
InterPro | LDLR_class-A_CS |
InterPro | LDLR_classB_rpt |
InterPro | LDrepeatLR_classA_rpt |
Pfam | EGF_CA |
Pfam | Ldl_recept_a |
Pfam | Ldl_recept_b |
Interactions
With (links to EBI) | #Exp | PubMed links |
---|---|---|
ENV_HV1H2 | 3 | 22190034 |
IF3M_HUMAN | 3 | 32296183 |
TLE5_HUMAN | 3 | 32296183 |
Protein can be found in apical membrane,
Protein can be found in basal membrane,
Protein can be found both membranes,
Localisation is unknown.