Gene name
LDLR
Experiment(s)
For this entry:
LDLR_HUMAN (LDLR)
| Species | Homo sapiens |
|---|---|
| Localization | Apical plasma membrane |
| Reference |
Fölsch H,Ohno H,Bonifacino JS,Mellman I (1999) A novel clathrin adaptor complex mediates basolateral targeting in polarized epithelial cells., Cell, 99, 189-98. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Kidney |
| Cell | LLC-PK1 cells (proximal tubule) |
| Notes | Source of vectors were not described properly. Expression of AP-1B causes basolateral sorting |
LDLR_HUMAN (LDLR)
| Species | Homo sapiens |
|---|---|
| Localization | Apical plasma membrane |
| Reference |
Sugimoto H,Sugahara M,Fölsch H,Koide Y,Nakatsu F,Tanaka N,Nishimura T,Furukawa M,Mullins C,Nakamura N,Mellman I,Ohno H (2002) Differential recognition of tyrosine-based basolateral signals by AP-1B subunit mu1B in polarized epithelial cells., Mol Biol Cell, 13, 2374-82. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Kidney |
| Cell | LLC-PK1 cells (proximal tubule) |
| Notes | Expression of AP-1B causes basolateral sorting |
LDLR_HUMAN (LDLR)
| Species | Homo sapiens |
|---|---|
| Localization | Basolateral plasma membrane |
| Reference |
Fölsch H,Ohno H,Bonifacino JS,Mellman I (1999) A novel clathrin adaptor complex mediates basolateral targeting in polarized epithelial cells., Cell, 99, 189-98. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Kidney |
| Cell | MDCK cells (distal tubule) |
| Notes | Source of vectors were not described |
LDLR_HUMAN (LDLR)
| Species | Homo sapiens |
|---|---|
| Localization | Basolateral plasma membrane |
| Reference |
Kang RS,Fölsch H (2011) ARH cooperates with AP-1B in the exocytosis of LDLR in polarized epithelial cells., J Cell Biol, 193, 51-60. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Lung |
| Cell | Airway epithel cells |
| Notes | Source of vectors were not described |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
| Start | End | Localisation |
|---|---|---|
| 1 | 21 | Signal peptide |
| 22 | 788 | Extracellular |
| 789 | 809 | Membrane |
| 810 | 860 | Cytoplasmic |
Phosphorylation
Glycosylation
Family and domain data
| Database | Domain/Family name |
|---|---|
| InterPro | 6-blade_b-propeller_TolB-like |
| InterPro | EGF-like_Ca-bd_dom |
| InterPro | EGF-like_dom |
| InterPro | EGF-type_Asp/Asn_hydroxyl_site |
| InterPro | EGF_Ca-bd_CS |
| InterPro | Growth_fac_rcpt_cys_sf |
| InterPro | LDL_receptor-like_sf |
| InterPro | LDLR_class-A_CS |
| InterPro | LDLR_classB_rpt |
| InterPro | LDrepeatLR_classA_rpt |
| Pfam | EGF_CA |
| Pfam | Ldl_recept_a |
| Pfam | Ldl_recept_b |
Interactions
| With (links to EBI) | #Exp | PubMed links |
|---|---|---|
| ENV_HV1H2 | 3 | 22190034 |
| IF3M_HUMAN | 3 | 32296183 |
| TLE5_HUMAN | 3 | 32296183 |
Protein can be found in apical membrane,
Protein can be found in basal membrane,
Protein can be found both membranes,
Localisation is unknown.