Gene name
KCNK1 (HOHO1,KCNO1,TWIK1)
Experiment(s)
For this entry:
KCNK1_HUMAN (KCNK1)
| Species | Homo sapiens |
|---|---|
| Localization | Apical plasma membrane |
| Reference |
Zhao KQ,Xiong G,Wilber M,Cohen NA,Kreindler JL (2012) A role for two-pore K⁺ channels in modulating Na⁺ absorption and Cl⁻ secretion in normal human bronchial epithelial cells., Am J Physiol Lung Cell Mol Physiol, 302, L4-L12. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Lung |
| Cell | Airway epithel cells |
| Notes |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
| Start | End | Localisation |
|---|---|---|
| 1 | 21 | Cytoplasmic |
| 22 | 44 | Membrane |
| 45 | 104 | Extracellular |
| 105 | 121 | Re-entrant loop |
| 122 | 128 | Extracellular |
| 129 | 156 | Membrane |
| 157 | 182 | Cytoplasmic |
| 183 | 206 | Membrane |
| 207 | 212 | Extracellular |
| 213 | 229 | Re-entrant loop |
| 230 | 243 | Extracellular |
| 244 | 268 | Membrane |
| 269 | 336 | Cytoplasmic |
Phosphorylation
Glycosylation
Family and domain data
| Database | Domain/Family name |
|---|---|
| InterPro | 2pore_dom_K_chnl |
| InterPro | 2pore_dom_K_chnl_TASK |
| InterPro | 2pore_dom_K_chnl_TWIK |
| InterPro | 2pore_dom_K_chnl_TWIK1 |
| InterPro | K_chnl_dom |
| Pfam | Ion_trans_2 |
Interactions
| With (links to EBI) | #Exp | PubMed links |
|---|---|---|
| CREB3_HUMAN | 2 | 31515488 |
| AQP6_HUMAN | 3 | 32296183 |
| CDIPT_HUMAN | 3 | 32296183 |
| ERGI3_HUMAN | 3 | 32296183 |
| CR3L1_HUMAN | 5 | 32296183 |
| STOM_HUMAN | 3 | 32296183 |
| TM139_HUMAN | 3 | 32296183 |
| TM14B_HUMAN | 3 | 32296183 |
Protein can be found in apical membrane,
Protein can be found in basal membrane,
Protein can be found both membranes,
Localisation is unknown.