Gene name
CXCL8 (IL8)
Experiment(s)
For this entry:
IL8_HUMAN (CXCL8)
| Species | Homo sapiens |
|---|---|
| Localization | Non polar membrane |
| Reference |
Krüger S,Brandt E,Klinger M,Kreft B (2000) Interleukin-8 secretion of cortical tubular epithelial cells is directed to the basolateral environment and is not enhanced by apical exposure to Escherichia coli., Infect Immun, 68, 328-34. [PubMed] [DOI] |
| Evidence level | Selective medium analysis |
| Organ | Kidney |
| Cell | Proximal tubules |
| Notes |
IL8_HUMAN (CXCL8)
| Species | Homo sapiens |
|---|---|
| Localization | Apical plasma membrane |
| Reference |
Chow AW,Liang JF,Wong JS,Fu Y,Tang NL,Ko WH (2010) Polarized secretion of interleukin (IL)-6 and IL-8 by human airway epithelia 16HBE14o- cells in response to cationic polypeptide challenge., PLoS One, 5, e12091. [PubMed] [DOI] |
| Evidence level | Selective medium analysis |
| Organ | Lung |
| Cell | 16HBE14o- cells (airway epithel cells) |
| Notes |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
| Start | End | Localisation |
|---|---|---|
| 1 | 99 | Extracellular |
Family and domain data
| Database | Domain/Family name |
|---|---|
| InterPro | Chemokine_CXC |
| InterPro | Chemokine_CXC_CS |
| InterPro | Chemokine_IL8-like_dom |
| InterPro | CXC_Chemokine_domain |
| InterPro | Interleukin-8 |
| InterPro | Interleukin_8-like_sf |
| Pfam | IL8 |
Interactions
| With (links to EBI) | #Exp | PubMed links |
|---|---|---|
| TSG6_HUMAN | 16 | 24501198 |
| CXCR2_HUMAN | 3 | 23597562 |
Protein can be found in apical membrane,
Protein can be found in basal membrane,
Protein can be found both membranes,
Localisation is unknown.