Gene name
Slc2a1 (Glut1)
Experiment(s)
For this entry:
GTR1_HUMAN (Slc2a1)
| Species | Homo sapiens |
|---|---|
| Localization | Basolateral plasma membrane |
| Reference |
Inukai K,Shewan AM,Pascoe WS,Katayama S,James DE,Oka Y (2004) Carboxy terminus of glucose transporter 3 contains an apical membrane targeting domain., Mol Endocrinol, 18, 339-49. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Kidney |
| Cell | MDCK cells (distal tubule) |
| Notes |
GTR1_HUMAN (Slc2a1)
| Species | Homo sapiens |
|---|---|
| Localization | Basolateral plasma membrane |
| Reference |
Harris DS,Slot JW,Geuze HJ,James DE (1992) Polarized distribution of glucose transporter isoforms in Caco-2 cells., Proc Natl Acad Sci U S A, 89, 7556-60. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Large intestine |
| Cell | CACO-2 cells (enterocytes) |
| Notes | Endogenous proteins |
GTR1_HUMAN (Slc2a1)
| Species | Homo sapiens |
|---|---|
| Localization | Non polar membrane |
| Reference |
Philp NJ,Wang D,Yoon H,Hjelmeland LM (2003) Polarized expression of monocarboxylate transporters in human retinal pigment epithelium and ARPE-19 cells., Invest Ophthalmol Vis Sci, 44, 1716-21. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Retina |
| Cell | Pigment epithel cells |
| Notes |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
| Start | End | Localisation |
|---|---|---|
| 1 | 14 | Cytoplasmic |
| 15 | 35 | Membrane |
| 36 | 65 | Extracellular |
| 66 | 86 | Membrane |
| 87 | 93 | Cytoplasmic |
| 94 | 113 | Membrane |
| 114 | 120 | Extracellular |
| 121 | 141 | Membrane |
| 142 | 155 | Cytoplasmic |
| 156 | 175 | Membrane |
| 176 | 187 | Extracellular |
| 188 | 207 | Membrane |
| 208 | 272 | Cytoplasmic |
| 273 | 292 | Membrane |
| 293 | 308 | Extracellular |
| 309 | 328 | Membrane |
| 329 | 335 | Cytoplasmic |
| 336 | 354 | Membrane |
| 355 | 367 | Extracellular |
| 368 | 389 | Membrane |
| 390 | 404 | Cytoplasmic |
| 405 | 426 | Membrane |
| 427 | 432 | Extracellular |
| 433 | 452 | Membrane |
| 453 | 492 | Cytoplasmic |
Phosphorylation
Glycosylation
Family and domain data
| Database | Domain/Family name |
|---|---|
| InterPro | Glu_transpt_1 |
| InterPro | MFS_dom |
| InterPro | MFS_sugar_transport-like |
| InterPro | MFS_trans_sf |
| InterPro | Sugar/inositol_transpt |
| InterPro | Sugar_transporter_CS |
| Pfam | Sugar_tr |
Interactions
| With (links to EBI) | #Exp | PubMed links |
|---|---|---|
| GTR1_HUMAN | 3 | 1429721 |
| ALDOA_HUMAN | 2 | 23219802 |
| VCAM1_HUMAN | 4 | 22623428 , 19738201 |
| CREB3_HUMAN | 3 | 25910212 |
| AQP1_HUMAN | 3 | 23219802 |
| ESR1_HUMAN | 2 | 31527615 |
| B3AT_HUMAN | 9 | 23219802 |
Protein can be found in apical membrane,
Protein can be found in basal membrane,
Protein can be found both membranes,
Localisation is unknown.