Gene name
CFTR (ABCC7)
Experiment(s)
For this entry:
CFTR_HUMAN (CFTR)
Species | Homo sapiens |
---|---|
Localization | Apical plasma membrane |
Reference |
Bidaud-Meynard A,Bossard F,Schnúr A,Fukuda R,Veit G,Xu H,Lukacs GL (2019) Transcytosis maintains CFTR apical polarity in the face of constitutive and mutation-induced basolateral missorting., J Cell Sci, 132, . [PubMed] [DOI] |
Evidence level | Antibody staining |
Organ | Lung |
Cell | CFBE cells (airway epithel) |
Notes |
CFTR_HUMAN (CFTR)
Species | Homo sapiens |
---|---|
Localization | Apical plasma membrane |
Reference |
Faller DP,Egan DA,Ryan MP (1995) Evidence for location of the CFTR in human placental apical membrane vesicles., Am J Physiol, 269, C148-55. [PubMed] [DOI] |
Evidence level | Membrane preparation |
Organ | Placenta |
Cell | Trophoblast cells |
Notes |
CFTR_HUMAN (CFTR)
Species | Homo sapiens |
---|---|
Localization | Apical plasma membrane |
Reference |
Mendes F,Wakefield J,Bachhuber T,Barroso M,Bebok Z,Penque D,Kunzelmann K,Amaral MD (2005) Establishment and characterization of a novel polarized MDCK epithelial cellular model for CFTR studies., Cell Physiol Biochem, 16, 281-90. [PubMed] [DOI] |
Evidence level | Antibody staining |
Organ | Kidney |
Cell | MDCK cells (distal tubule) |
Notes |
CFTR_HUMAN (CFTR)
Species | Homo sapiens |
---|---|
Localization | Apical plasma membrane |
Reference |
Crawford I,Maloney PC,Zeitlin PL,Guggino WB,Hyde SC,Turley H,Gatter KC,Harris A,Higgins CF (1991) Immunocytochemical localization of the cystic fibrosis gene product CFTR., Proc Natl Acad Sci U S A, 88, 9262-6. [PubMed] [DOI] |
Evidence level | Antibody staining |
Organ | Pancreas |
Cell | Ductal cells |
Notes |
CFTR_HUMAN (CFTR)
Species | Homo sapiens |
---|---|
Localization | Apical plasma membrane |
Reference |
Crawford I,Maloney PC,Zeitlin PL,Guggino WB,Hyde SC,Turley H,Gatter KC,Harris A,Higgins CF (1991) Immunocytochemical localization of the cystic fibrosis gene product CFTR., Proc Natl Acad Sci U S A, 88, 9262-6. [PubMed] [DOI] |
Evidence level | Antibody staining |
Organ | Sweat glands |
Cell | Ductal cells |
Notes |
CFTR_HUMAN (CFTR)
Species | Homo sapiens |
---|---|
Localization | Apical plasma membrane |
Reference |
Crawford I,Maloney PC,Zeitlin PL,Guggino WB,Hyde SC,Turley H,Gatter KC,Harris A,Higgins CF (1991) Immunocytochemical localization of the cystic fibrosis gene product CFTR., Proc Natl Acad Sci U S A, 88, 9262-6. [PubMed] [DOI] |
Evidence level | Antibody staining |
Organ | Kidney |
Cell | Proximal tubules |
Notes |
CFTR_HUMAN (CFTR)
Species | Homo sapiens |
---|---|
Localization | Apical plasma membrane |
Reference |
Crawford I,Maloney PC,Zeitlin PL,Guggino WB,Hyde SC,Turley H,Gatter KC,Harris A,Higgins CF (1991) Immunocytochemical localization of the cystic fibrosis gene product CFTR., Proc Natl Acad Sci U S A, 88, 9262-6. [PubMed] [DOI] |
Evidence level | Antibody staining |
Organ | Lung |
Cell | Airway epithel cells |
Notes |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
Start | End | Localisation |
---|---|---|
1 | 76 | Cytoplasmic |
77 | 97 | Membrane |
98 | 120 | Extracellular |
121 | 142 | Membrane |
143 | 195 | Cytoplasmic |
196 | 216 | Membrane |
217 | 220 | Extracellular |
221 | 241 | Membrane |
242 | 303 | Cytoplasmic |
304 | 325 | Membrane |
326 | 330 | Extracellular |
331 | 351 | Membrane |
352 | 858 | Cytoplasmic |
859 | 880 | Membrane |
881 | 914 | Extracellular |
915 | 935 | Membrane |
936 | 988 | Cytoplasmic |
989 | 1009 | Membrane |
1010 | 1013 | Extracellular |
1014 | 1034 | Membrane |
1035 | 1100 | Cytoplasmic |
1101 | 1121 | Membrane |
1122 | 1126 | Extracellular |
1127 | 1147 | Membrane |
1148 | 1480 | Cytoplasmic |
Eukaryotic Linear Motif (ELM)
Start | End | Sequence | Motif |
---|---|---|---|
1476 | 1480 | QDTRL | TRG_PTS1 |
Phosphorylation
Position | Resource |
---|---|
45 | 34348743 |
50 | 34348746 |
94 | 34362518 |
256 | 23093383 |
291 | 18007913 |
421 | 1382554800 |
422 | 3333404 |
427 | 1382554801 |
511 | 477193 |
512 | 21041602 |
515 | 484645 |
549 | 18007916 |
582 | 2907507 |
604 | 2907506 |
605 | 10407900 |
641 | 2907508 |
660 | 449979 |
670 | 3333405 |
682 | 2907505 |
686 | 449980 |
700 | 449978 |
707 | 2907509 |
712 | 455297 |
737 | 449981 |
753 | 451646 |
768 | 455300 |
774 | 23093391 |
776 | 23093386 |
790 | 2907510 |
795 | 449982 |
809 | 2999001 |
813 | 449983 |
816 | 28847000 |
1014 | 23093394 |
1019 | 23093388 |
1045 | 56689900 |
1176 | 36276206 |
1362 | 18007910 |
1424 | 3672296 |
1455 | 36698118 |
1456 | 36698121 |
1471 | 21440502 |
Glycosylation
Family and domain data
Database | Domain/Family name |
---|---|
InterPro | AAA+_ATPase |
InterPro | ABC1_TM_dom |
InterPro | ABC1_TM_sf |
InterPro | ABC_transporter-like |
InterPro | ABC_transporter_CS |
InterPro | CFTR/ABCC7 |
InterPro | CFTR_reg_dom |
InterPro | P-loop_NTPase |
Pfam | ABC_membrane |
Pfam | ABC_tran |
Pfam | CFTR_R |
Interactions
Protein can be found in apical membrane,
Protein can be found in basal membrane,
Protein can be found both membranes,
Localisation is unknown.