Gene name
CFTR (ABCC7)
Experiment(s)
For this entry:
CFTR_HUMAN (CFTR)
| Species | Homo sapiens |
|---|---|
| Localization | Apical plasma membrane |
| Reference |
Bidaud-Meynard A,Bossard F,Schnúr A,Fukuda R,Veit G,Xu H,Lukacs GL (2019) Transcytosis maintains CFTR apical polarity in the face of constitutive and mutation-induced basolateral missorting., J Cell Sci, 132, . [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Lung |
| Cell | CFBE cells (airway epithel) |
| Notes |
CFTR_HUMAN (CFTR)
| Species | Homo sapiens |
|---|---|
| Localization | Apical plasma membrane |
| Reference |
Faller DP,Egan DA,Ryan MP (1995) Evidence for location of the CFTR in human placental apical membrane vesicles., Am J Physiol, 269, C148-55. [PubMed] [DOI] |
| Evidence level | Membrane preparation |
| Organ | Placenta |
| Cell | Trophoblast cells |
| Notes |
CFTR_HUMAN (CFTR)
| Species | Homo sapiens |
|---|---|
| Localization | Apical plasma membrane |
| Reference |
Mendes F,Wakefield J,Bachhuber T,Barroso M,Bebok Z,Penque D,Kunzelmann K,Amaral MD (2005) Establishment and characterization of a novel polarized MDCK epithelial cellular model for CFTR studies., Cell Physiol Biochem, 16, 281-90. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Kidney |
| Cell | MDCK cells (distal tubule) |
| Notes |
CFTR_HUMAN (CFTR)
| Species | Homo sapiens |
|---|---|
| Localization | Apical plasma membrane |
| Reference |
Crawford I,Maloney PC,Zeitlin PL,Guggino WB,Hyde SC,Turley H,Gatter KC,Harris A,Higgins CF (1991) Immunocytochemical localization of the cystic fibrosis gene product CFTR., Proc Natl Acad Sci U S A, 88, 9262-6. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Pancreas |
| Cell | Ductal cells |
| Notes |
CFTR_HUMAN (CFTR)
| Species | Homo sapiens |
|---|---|
| Localization | Apical plasma membrane |
| Reference |
Crawford I,Maloney PC,Zeitlin PL,Guggino WB,Hyde SC,Turley H,Gatter KC,Harris A,Higgins CF (1991) Immunocytochemical localization of the cystic fibrosis gene product CFTR., Proc Natl Acad Sci U S A, 88, 9262-6. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Sweat glands |
| Cell | Ductal cells |
| Notes |
CFTR_HUMAN (CFTR)
| Species | Homo sapiens |
|---|---|
| Localization | Apical plasma membrane |
| Reference |
Crawford I,Maloney PC,Zeitlin PL,Guggino WB,Hyde SC,Turley H,Gatter KC,Harris A,Higgins CF (1991) Immunocytochemical localization of the cystic fibrosis gene product CFTR., Proc Natl Acad Sci U S A, 88, 9262-6. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Kidney |
| Cell | Proximal tubules |
| Notes |
CFTR_HUMAN (CFTR)
| Species | Homo sapiens |
|---|---|
| Localization | Apical plasma membrane |
| Reference |
Crawford I,Maloney PC,Zeitlin PL,Guggino WB,Hyde SC,Turley H,Gatter KC,Harris A,Higgins CF (1991) Immunocytochemical localization of the cystic fibrosis gene product CFTR., Proc Natl Acad Sci U S A, 88, 9262-6. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Lung |
| Cell | Airway epithel cells |
| Notes |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
| Start | End | Localisation |
|---|---|---|
| 1 | 76 | Cytoplasmic |
| 77 | 97 | Membrane |
| 98 | 120 | Extracellular |
| 121 | 142 | Membrane |
| 143 | 195 | Cytoplasmic |
| 196 | 216 | Membrane |
| 217 | 220 | Extracellular |
| 221 | 241 | Membrane |
| 242 | 303 | Cytoplasmic |
| 304 | 325 | Membrane |
| 326 | 330 | Extracellular |
| 331 | 351 | Membrane |
| 352 | 858 | Cytoplasmic |
| 859 | 880 | Membrane |
| 881 | 914 | Extracellular |
| 915 | 935 | Membrane |
| 936 | 988 | Cytoplasmic |
| 989 | 1009 | Membrane |
| 1010 | 1013 | Extracellular |
| 1014 | 1034 | Membrane |
| 1035 | 1100 | Cytoplasmic |
| 1101 | 1121 | Membrane |
| 1122 | 1126 | Extracellular |
| 1127 | 1147 | Membrane |
| 1148 | 1480 | Cytoplasmic |
Eukaryotic Linear Motif (ELM)
| Start | End | Sequence | Motif |
|---|---|---|---|
| 1476 | 1480 | QDTRL | TRG_PTS1 |
Phosphorylation
| Position | Resource |
|---|---|
| 45 | 34348743 |
| 50 | 34348746 |
| 94 | 34362518 |
| 256 | 23093383 |
| 291 | 18007913 |
| 421 | 1382554800 |
| 422 | 3333404 |
| 427 | 1382554801 |
| 511 | 477193 |
| 512 | 21041602 |
| 515 | 484645 |
| 549 | 18007916 |
| 582 | 2907507 |
| 604 | 2907506 |
| 605 | 10407900 |
| 641 | 2907508 |
| 660 | 449979 |
| 670 | 3333405 |
| 682 | 2907505 |
| 686 | 449980 |
| 700 | 449978 |
| 707 | 2907509 |
| 712 | 455297 |
| 737 | 449981 |
| 753 | 451646 |
| 768 | 455300 |
| 774 | 23093391 |
| 776 | 23093386 |
| 790 | 2907510 |
| 795 | 449982 |
| 809 | 2999001 |
| 813 | 449983 |
| 816 | 28847000 |
| 1014 | 23093394 |
| 1019 | 23093388 |
| 1045 | 56689900 |
| 1176 | 36276206 |
| 1362 | 18007910 |
| 1424 | 3672296 |
| 1455 | 36698118 |
| 1456 | 36698121 |
| 1471 | 21440502 |
Glycosylation
Family and domain data
| Database | Domain/Family name |
|---|---|
| InterPro | AAA+_ATPase |
| InterPro | ABC1_TM_dom |
| InterPro | ABC1_TM_sf |
| InterPro | ABC_transporter-like |
| InterPro | ABC_transporter_CS |
| InterPro | CFTR/ABCC7 |
| InterPro | CFTR_reg_dom |
| InterPro | P-loop_NTPase |
| Pfam | ABC_membrane |
| Pfam | ABC_tran |
| Pfam | CFTR_R |
Interactions
Protein can be found in apical membrane,
Protein can be found in basal membrane,
Protein can be found both membranes,
Localisation is unknown.