Gene name
CFTR (ABCC7)
Experiment(s)
For this entry:
CFTR_RAT (CFTR)
| Species | Rattus norvegicus |
|---|---|
| Localization | Apical plasma membrane |
| Reference |
Jakab RL,Collaco AM,Ameen NA (2011) Physiological relevance of cell-specific distribution patterns of CFTR, NKCC1, NBCe1, and NHE3 along the crypt-villus axis in the intestine., Am J Physiol Gastrointest Liver Physiol, 300, G82-98. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Small intestine |
| Cell | Enterocytes |
| Notes |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
| Start | End | Localisation |
|---|---|---|
| 1 | 75 | Cytoplasmic |
| 76 | 97 | Membrane |
| 98 | 120 | Extracellular |
| 121 | 142 | Membrane |
| 143 | 194 | Cytoplasmic |
| 195 | 215 | Membrane |
| 216 | 220 | Extracellular |
| 221 | 241 | Membrane |
| 242 | 303 | Cytoplasmic |
| 304 | 325 | Membrane |
| 326 | 330 | Extracellular |
| 331 | 351 | Membrane |
| 352 | 853 | Cytoplasmic |
| 854 | 875 | Membrane |
| 876 | 909 | Extracellular |
| 910 | 931 | Membrane |
| 932 | 984 | Cytoplasmic |
| 985 | 1005 | Membrane |
| 1006 | 1008 | Extracellular |
| 1009 | 1029 | Membrane |
| 1030 | 1097 | Cytoplasmic |
| 1098 | 1117 | Membrane |
| 1118 | 1122 | Extracellular |
| 1123 | 1142 | Membrane |
| 1143 | 1476 | Cytoplasmic |
Eukaryotic Linear Motif (ELM)
| Start | End | Sequence | Motif |
|---|---|---|---|
| 1472 | 1476 | QETRL | TRG_PTS1 |
Phosphorylation
Family and domain data
| Database | Domain/Family name |
|---|---|
| InterPro | AAA+_ATPase |
| InterPro | ABC1_TM_dom |
| InterPro | ABC1_TM_sf |
| InterPro | ABC_transporter-like |
| InterPro | ABC_transporter_CS |
| InterPro | CFTR/ABCC7 |
| InterPro | CFTR_reg_dom |
| InterPro | P-loop_NTPase |
| Pfam | ABC_membrane |
| Pfam | ABC_tran |
| Pfam | CFTR_R |