Gene name
CFI (IF)
Experiment(s)
For this entry:
CFAI_HUMAN (CFI)
| Species | Homo sapiens |
|---|---|
| Localization | Basolateral plasma membrane |
| Reference |
Touzelet O,Broadbent L,Armstrong SD,Aljabr W,Cloutman-Green E,Power UF,Hiscox JA (2020) The Secretome Profiling of a Pediatric Airway Epithelium Infected with hRSV Identified Aberrant Apical/Basolateral Trafficking and Novel Immune Modulating (CXCL6, CXCL16, CSF3) and Antiviral (CEACAM1) Proteins., Mol Cell Proteomics, 19, 793-807. [PubMed] [DOI] |
| Evidence level | Large-scale proteomics |
| Organ | Lung |
| Cell | Airway epithel cells |
| Notes | Only mock-transfected cells were considered |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
| Start | End | Localisation |
|---|---|---|
| 1 | 583 | Extracellular |
Phosphorylation
Glycosylation
Family and domain data
| Database | Domain/Family name |
|---|---|
| InterPro | FacI_MAC |
| InterPro | Kazal_dom |
| InterPro | Kazal_dom_sf |
| InterPro | LDL_receptor-like_sf |
| InterPro | LDLR_class-A_CS |
| InterPro | LDrepeatLR_classA_rpt |
| InterPro | Peptidase_S1_PA |
| InterPro | Peptidase_S1_PA_chymotrypsin |
| InterPro | Peptidase_S1A |
| InterPro | SRCR |
| InterPro | SRCR-like_dom |
| InterPro | SRCR-like_dom_sf |
| InterPro | Trypsin_dom |
| InterPro | TRYPSIN_HIS |
| InterPro | TRYPSIN_SER |
| Pfam | Ldl_recept_a |
| Pfam | SRCR |
| Pfam | Trypsin |
Interactions
| With (links to EBI) | #Exp | PubMed links |
|---|---|---|
| CRP_HUMAN | 2 | 21930971 |
| CO3_HUMAN | 9 | 17399790 , 21930971 , 24260121 , 18796626 , 25305316 |
| PTX3_HUMAN | 2 | 22786770 |
| CFAH_HUMAN | 11 | 19680263 , 17399790 , 21930971 , 25305316 , 22786770 |
| ALBU_BOVIN | 2 | 21979047 |
Protein can be found in apical membrane,
Protein can be found in basal membrane,
Protein can be found both membranes,
Localisation is unknown.