Gene name
CFB (BF,BFD)
Experiment(s)
For this entry:
CFAB_HUMAN (CFB)
Species | Homo sapiens |
---|---|
Localization | Apical plasma membrane |
Reference |
Touzelet O,Broadbent L,Armstrong SD,Aljabr W,Cloutman-Green E,Power UF,Hiscox JA (2020) The Secretome Profiling of a Pediatric Airway Epithelium Infected with hRSV Identified Aberrant Apical/Basolateral Trafficking and Novel Immune Modulating (CXCL6, CXCL16, CSF3) and Antiviral (CEACAM1) Proteins., Mol Cell Proteomics, 19, 793-807. [PubMed] [DOI] |
Evidence level | Large-scale proteomics |
Organ | Lung |
Cell | Airway epithel cells |
Notes | Only mock-transfected cells were considered |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
Start | End | Localisation |
---|---|---|
1 | 764 | Extracellular |
Phosphorylation
Glycosylation
Family and domain data
Database | Domain/Family name |
---|---|
InterPro | Compl_C2_B |
InterPro | Complement_B |
InterPro | Peptidase_S1_PA |
InterPro | Peptidase_S1_PA_chymotrypsin |
InterPro | Peptidase_S1A |
InterPro | Sushi/SCR/CCP_sf |
InterPro | Sushi_SCR_CCP_dom |
InterPro | Trypsin_dom |
InterPro | TRYPSIN_HIS |
InterPro | TRYPSIN_SER |
InterPro | VWF_A |
InterPro | vWFA_dom_sf |
Pfam | Sushi |
Pfam | Trypsin |
Pfam | VWA |
Interactions
With (links to EBI) | #Exp | PubMed links |
---|---|---|
FHR4_HUMAN | 4 | 28533443 , 22518841 |
Protein can be found in apical membrane,
Protein can be found in basal membrane,
Protein can be found both membranes,
Localisation is unknown.