Gene name
Ca4
Experiment(s)
For this entry:
CAH4_HUMAN (Ca4)
| Species | Homo sapiens |
|---|---|
| Localization | Apical plasma membrane |
| Reference |
Wolfensberger TJ,Mahieu I,Jarvis-Evans J,Boulton M,Carter ND,Nógrádi A,Hollande E,Bird AC (1994) Membrane-bound carbonic anhydrase in human retinal pigment epithelium., Invest Ophthalmol Vis Sci, 35, 3401-7. [PubMed] |
| Evidence level | Other |
| Organ | Retina |
| Cell | Pigment epithel cells |
| Notes | An activity-based histochemical method was used |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
| Start | End | Localisation |
|---|---|---|
| 1 | 20 | Signal peptide |
| 21 | 290 | Extracellular |
| 291 | 311 | Membrane |
| 312 | 312 | Cytoplasmic |
Phosphorylation
Family and domain data
| Database | Domain/Family name |
|---|---|
| InterPro | CA4/CA15 |
| InterPro | CA_dom |
| InterPro | CA_dom_sf |
| InterPro | Carbonic_anhydrase_a-class |
| InterPro | Carbonic_anhydrase_a-class_CS |
| InterPro | Carbonic_anhydrase_CA4 |
| Pfam | Carb_anhydrase |