Gene name
AGRN (AGRIN)
Experiment(s)
For this entry:
AGRIN_HUMAN (AGRN)
| Species | Homo sapiens |
|---|---|
| Localization | Non polar membrane |
| Reference |
Touzelet O,Broadbent L,Armstrong SD,Aljabr W,Cloutman-Green E,Power UF,Hiscox JA (2020) The Secretome Profiling of a Pediatric Airway Epithelium Infected with hRSV Identified Aberrant Apical/Basolateral Trafficking and Novel Immune Modulating (CXCL6, CXCL16, CSF3) and Antiviral (CEACAM1) Proteins., Mol Cell Proteomics, 19, 793-807. [PubMed] [DOI] |
| Evidence level | Large-scale proteomics |
| Organ | Lung |
| Cell | Airway epithel cells |
| Notes |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
| Start | End | Localisation |
|---|---|---|
| 1 | 2068 | Extracellular |
Phosphorylation
Glycosylation
Family and domain data
| Database | Domain/Family name |
|---|---|
| InterPro | ConA-like_dom_sf |
| InterPro | EGF-like_Ca-bd_dom |
| InterPro | EGF-like_dom |
| InterPro | FacI_MAC |
| InterPro | Fol_N |
| InterPro | Kazal_dom |
| InterPro | Kazal_dom_sf |
| InterPro | Laminin_EGF |
| InterPro | Laminin_G |
| InterPro | NtA_dom |
| InterPro | SEA_dom |
| InterPro | SEA_dom_sf |
| InterPro | TIMP-like_OB-fold |
| Pfam | EGF |
| Pfam | Kazal_1 |
| Pfam | Kazal_2 |
| Pfam | Laminin_EGF |
| Pfam | Laminin_G_1 |
| Pfam | NtA |
| Pfam | SEA |
Interactions
| With (links to EBI) | #Exp | PubMed links |
|---|---|---|
| ATX7_HUMAN | 2 | 21078624 |
| MERL_HUMAN | 2 | 28514442 |
| ESR1_HUMAN | 2 | 31527615 |
| A4_HUMAN | 3 | 10673326 |
Protein can be found in apical membrane,
Protein can be found in basal membrane,
Protein can be found both membranes,
Localisation is unknown.