Gene name
ACE2
Experiment(s)
For this entry:
ACE2_HUMAN (ACE2)
| Species | Homo sapiens |
|---|---|
| Localization | Apical plasma membrane |
| Reference |
Ren X,Glende J,Al-Falah M,de Vries V,Schwegmann-Wessels C,Qu X,Tan L,Tschernig T,Deng H,Naim HY,Herrler G (2006) Analysis of ACE2 in polarized epithelial cells: surface expression and function as receptor for severe acute respiratory syndrome-associated coronavirus., J Gen Virol, 87, 1691-5. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Large intestine |
| Cell | CACO-2 cells (enterocytes) |
| Notes |
ACE2_HUMAN (ACE2)
| Species | Homo sapiens |
|---|---|
| Localization | Apical plasma membrane |
| Reference |
Ortiz Bezara ME,Thurman A,Pezzulo AA,Leidinger MR,Klesney-Tait JA,Karp PH,Tan P,Wohlford-Lenane C,McCray PB Jr,Meyerholz DK (2020) Heterogeneous expression of the SARS-Coronavirus-2 receptor ACE2 in the human respiratory tract., bioRxiv, , . [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Lung |
| Cell | Airway epithel cells |
| Notes |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
| Start | End | Localisation |
|---|---|---|
| 1 | 17 | Signal peptide |
| 18 | 740 | Extracellular |
| 741 | 763 | Membrane |
| 764 | 805 | Cytoplasmic |
Phosphorylation
Glycosylation
Family and domain data
| Database | Domain/Family name |
|---|---|
| InterPro | Collectrin_dom |
| InterPro | Peptidase_M2 |
| Pfam | Collectrin |
| Pfam | Peptidase_M2 |
Interactions
| With (links to EBI) | #Exp | PubMed links |
|---|---|---|
| ITB1_HUMAN | 4 | 22523556 |
| S6A19_HUMAN | 3 | 32132184 |
| SPIKE_CVHSA | 42 | 32203189 , 30102747 , 32225175 , 14647384 , 32155444 , 18931070 , 22291007 , 15791205 , 32275855 , 32332765 , 32075877 , 32415260 , 15479853 , unassigned2454 , 32376634 |
| DEF5_HUMAN | 2 | unassigned2457 |
| SPIKE_CVHNL | 3 | 18931070 |
| ACE2_HUMAN | 3 | 32275855 , 32203189 |
| Q5GDB5_CVHSA | 2 | 15791205 |
| SPIKE_SARS2 | 35 | 32203189 , 32225176 , 32225175 , 32132184 , 32155444 , 32275855 , 32332765 , 32075877 , 32415260 , unassigned2454 , unassigned2457 , 32376634 , 32607506 |
Protein can be found in apical membrane,
Protein can be found in basal membrane,
Protein can be found both membranes,
Localisation is unknown.