Gene name
ACE2
Experiment(s)
For this entry:
ACE2_HUMAN (ACE2)
Species | Homo sapiens |
---|---|
Localization | Apical plasma membrane |
Reference |
Ren X,Glende J,Al-Falah M,de Vries V,Schwegmann-Wessels C,Qu X,Tan L,Tschernig T,Deng H,Naim HY,Herrler G (2006) Analysis of ACE2 in polarized epithelial cells: surface expression and function as receptor for severe acute respiratory syndrome-associated coronavirus., J Gen Virol, 87, 1691-5. [PubMed] [DOI] |
Evidence level | Antibody staining |
Organ | Large intestine |
Cell | CACO-2 cells (enterocytes) |
Notes |
ACE2_HUMAN (ACE2)
Species | Homo sapiens |
---|---|
Localization | Apical plasma membrane |
Reference |
Ortiz Bezara ME,Thurman A,Pezzulo AA,Leidinger MR,Klesney-Tait JA,Karp PH,Tan P,Wohlford-Lenane C,McCray PB Jr,Meyerholz DK (2020) Heterogeneous expression of the SARS-Coronavirus-2 receptor ACE2 in the human respiratory tract., bioRxiv, , . [PubMed] [DOI] |
Evidence level | Antibody staining |
Organ | Lung |
Cell | Airway epithel cells |
Notes |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
Start | End | Localisation |
---|---|---|
1 | 17 | Signal peptide |
18 | 740 | Extracellular |
741 | 763 | Membrane |
764 | 805 | Cytoplasmic |