Gene name
ABCG2 (Abcp,BCRP,Bcrp1,MXR,BMDP)
Experiment(s)
For this entry:
ABCG2_RAT (ABCG2)
| Species | Rattus norvegicus |
|---|---|
| Localization | Apical plasma membrane |
| Reference |
Roberts LM,Black DS,Raman C,Woodford K,Zhou M,Haggerty JE,Yan AT,Cwirla SE,Grindstaff KK (2008) Subcellular localization of transporters along the rat blood-brain barrier and blood-cerebral-spinal fluid barrier by in vivo biotinylation., Neuroscience, 155, 423-38. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Vessels |
| Cell | Brain capillary endothelial cells |
| Notes |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
| Start | End | Localisation |
|---|---|---|
| 1 | 392 | Cytoplasmic |
| 393 | 414 | Membrane |
| 415 | 427 | Extracellular |
| 428 | 449 | Membrane |
| 450 | 476 | Cytoplasmic |
| 477 | 498 | Membrane |
| 499 | 505 | Extracellular |
| 506 | 527 | Membrane |
| 528 | 534 | Cytoplasmic |
| 535 | 556 | Membrane |
| 557 | 629 | Extracellular |
| 630 | 651 | Membrane |
| 652 | 657 | Cytoplasmic |
Phosphorylation
Family and domain data
| Database | Domain/Family name |
|---|---|
| InterPro | AAA+_ATPase |
| InterPro | ABC_2_trans |
| InterPro | ABC_transporter-like |
| InterPro | ABCG2 |
| InterPro | P-loop_NTPase |
| Pfam | ABC2_membrane |
| Pfam | ABC_tran |