Gene name
ABCG2 (Abcp,BCRP,Bcrp1,MXR,BMDP)
Experiment(s)
For this entry:
ABCG2_PIG (ABCG2)
| Species | Sus scrofa |
|---|---|
| Localization | Apical plasma membrane |
| Reference |
Woodward OM,Köttgen A,Coresh J,Boerwinkle E,Guggino WB,Köttgen M (2009) Identification of a urate transporter, ABCG2, with a common functional polymorphism causing gout., Proc Natl Acad Sci U S A, 106, 10338-42. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Kidney |
| Cell | LLC-PK1 cells (proximal tubule) |
| Notes |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
| Start | End | Localisation |
|---|---|---|
| 1 | 394 | Cytoplasmic |
| 395 | 415 | Membrane |
| 416 | 428 | Extracellular |
| 429 | 449 | Membrane |
| 450 | 477 | Cytoplasmic |
| 478 | 498 | Membrane |
| 499 | 506 | Extracellular |
| 507 | 528 | Membrane |
| 529 | 536 | Cytoplasmic |
| 537 | 557 | Membrane |
| 558 | 630 | Extracellular |
| 631 | 651 | Membrane |
| 652 | 656 | Cytoplasmic |
Family and domain data
| Database | Domain/Family name |
|---|---|
| InterPro | AAA+_ATPase |
| InterPro | ABC_2_trans |
| InterPro | ABC_transporter-like |
| InterPro | ABCG2 |
| InterPro | P-loop_NTPase |
| Pfam | ABC2_membrane |
| Pfam | ABC_tran |