Gene name
SERPINA1 (AAT,PI)
Experiment(s)
For this entry:
A1AT_HUMAN (SERPINA1)
Species | Homo sapiens |
---|---|
Localization | Apical plasma membrane |
Reference |
Touzelet O,Broadbent L,Armstrong SD,Aljabr W,Cloutman-Green E,Power UF,Hiscox JA (2020) The Secretome Profiling of a Pediatric Airway Epithelium Infected with hRSV Identified Aberrant Apical/Basolateral Trafficking and Novel Immune Modulating (CXCL6, CXCL16, CSF3) and Antiviral (CEACAM1) Proteins., Mol Cell Proteomics, 19, 793-807. [PubMed] [DOI] |
Evidence level | Large-scale proteomics |
Organ | Lung |
Cell | Airway epithel cells |
Notes | Only mock-transfected cells were considered |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
Start | End | Localisation |
---|---|---|
1 | 418 | Extracellular |
Phosphorylation
Glycosylation
Family and domain data
Database | Domain/Family name |
---|---|
InterPro | Serpin_CS |
InterPro | Serpin_dom |
InterPro | Serpin_fam |
InterPro | Serpin_sf |
InterPro | Serpin_sf_1 |
InterPro | Serpin_sf_2 |
Pfam | Serpin |
Interactions
With (links to EBI) | #Exp | PubMed links |
---|---|---|
P71213_ECOLX | 3 | 15271889 |
TRY1_BOVIN | 3 | 16321984 , 11057674 , 12860985 |
CELA1_PIG | 2 | 16321984 |
Protein can be found in apical membrane,
Protein can be found in basal membrane,
Protein can be found both membranes,
Localisation is unknown.