Gene name
TG
Experiment(s)
For this entry:
THYG_BOVIN (TG)
| Species | Bos taurus |
|---|---|
| Localization | Apical plasma membrane |
| Reference |
Martín-Belmonte F,Arvan P,Alonso MA (2001) MAL mediates apical transport of secretory proteins in polarized epithelial Madin-Darby canine kidney cells., J Biol Chem, 276, 49337-42. [PubMed] [DOI] |
| Evidence level | Membrane preparation |
| Organ | Kidney |
| Cell | MDCK cells (distal tubule) |
| Notes |
THYG_BOVIN (TG)
| Species | Bos taurus |
|---|---|
| Localization | Apical plasma membrane |
| Reference |
Martin-Belmonte F,Alonso MA,Zhang X,Arvan P (2000) Thyroglobulin is selected as luminal protein cargo for apical transport via detergent-resistant membranes in epithelial cells., J Biol Chem, 275, 41074-81. [PubMed] [DOI] |
| Evidence level | Membrane preparation |
| Organ | Thyroid gland |
| Cell | FRT cells (follicular cells) |
| Notes |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
| Start | End | Localisation |
|---|---|---|
| 1 | 2769 | Extracellular |
Glycosylation
| Position | Site resource | Glycan resource | PubMed link(s) |
|---|---|---|---|
| 110 | UniProtKB | 8424663 , 8424663 | |
| 110 | dbPTM | 8424663 | |
| 483 | UniProtKB | 8424663 , 8424663 | |
| 483 | dbPTM | 8424663 | |
| 495 | UniProtKB | 8424663 , 8424663 | |
| 495 | dbPTM | 8424663 | |
| 853 | UniProtKB | 8424663 , 8424663 | |
| 853 | dbPTM | 8424663 | |
| 947 | UniProtKB | 8424663 , 8424663 | |
| 947 | dbPTM | 8424663 | |
| 1140 | UniProtKB | 8424663 , 8424663 | |
| 1140 | dbPTM | 8424663 | |
| 1365 | UniProtKB | 8424663 | |
| 1365 | dbPTM | 8424663 | |
| 1776 | UniProtKB | 8424663 , 8424663 | |
| 1776 | dbPTM | 8424663 | |
| 1870 | UniProtKB | 8424663 , 8424663 | |
| 1870 | dbPTM | 8424663 | |
| 2014 | dbPTM | 8424663 | |
| 2014 | UniProtKB | 8424663 | |
| 2123 | dbPTM | 8424663 | |
| 2123 | UniProtKB | 8424663 | |
| 2251 | dbPTM | 8424663 | |
| 2251 | UniProtKB | 8424663 , 8424663 | |
| 2296 | dbPTM | 8424663 | |
| 2296 | UniProtKB | 8424663 |
Family and domain data
| Database | Domain/Family name |
|---|---|
| InterPro | AB_hydrolase |
| InterPro | CarbesteraseB |
| InterPro | Carboxylesterase_B_CS |
| InterPro | Growth_fac_rcpt_cys_sf |
| InterPro | Thyroglobulin |
| InterPro | Thyroglobulin_1 |
| InterPro | Thyroglobulin_1_sf |
| InterPro | Tyr-kin_ephrin_A/B_rcpt-like |
| Pfam | COesterase |
| Pfam | Ephrin_rec_like |
| Pfam | Thyroglobulin_1 |