Gene name
SI
Experiment(s)
For this entry:
SUIS_HUMAN (SI)
| Species | Homo sapiens |
|---|---|
| Localization | Apical plasma membrane |
| Reference |
Alfalah M,Jacob R,Preuss U,Zimmer KP,Naim H,Naim HY (1999) O-linked glycans mediate apical sorting of human intestinal sucrase-isomaltase through association with lipid rafts., Curr Biol, 9, 593-6. [PubMed] [DOI] |
| Evidence level | Membrane preparation |
| Organ | Kidney |
| Cell | MDCK cells (distal tubule) |
| Notes | Detected by western blotting the apical or basolateral membrane preparates |
SUIS_HUMAN (SI)
| Species | Homo sapiens |
|---|---|
| Localization | Apical plasma membrane |
| Reference |
Delacour D,Cramm-Behrens CI,Drobecq H,Le Bivic A,Naim HY,Jacob R (2006) Requirement for galectin-3 in apical protein sorting., Curr Biol, 16, 408-14. [PubMed] [DOI] |
| Evidence level | Fluorescent tagging |
| Organ | Kidney |
| Cell | MDCK cells (distal tubule) |
| Notes |
SUIS_HUMAN (SI)
| Species | Homo sapiens |
|---|---|
| Localization | Apical plasma membrane |
| Reference |
Pshezhetsky AV,Fedjaev M,Ashmarina L,Mazur A,Budman L,Sinnett D,Labuda D,Beaulieu JF,Ménard D,Nifant'ev I,Levy E (2007) Subcellular proteomics of cell differentiation: quantitative analysis of the plasma membrane proteome of Caco-2 cells., Proteomics, 7, 2201-15. [PubMed] [DOI] |
| Evidence level | Large-scale proteomics |
| Organ | Large intestine |
| Cell | CACO-2 cells (enterocytes) |
| Notes | Cutoff: at least 4-fold enrichment (A/total) at any repetition |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
| Start | End | Localisation |
|---|---|---|
| 1 | 10 | Cytoplasmic |
| 11 | 31 | Membrane |
| 32 | 1827 | Extracellular |
Phosphorylation
Glycosylation
| Position | Site resource | Glycan resource | PubMed link(s) |
|---|---|---|---|
| 99 | UniProtKB | 20356844 | |
| 99 | dbPTM | 20356844 | |
| 437 | PolarProtDb | 31844046 | |
| 437 | N-GlycoSiteAtlas | 25247386 | |
| 455 | dbPTM | 20356844 | |
| 455 | UniProtKB | 20356844 | |
| 823 | N-GlycoSiteAtlas | ||
| 855 | dbPTM | 20356844 | |
| 855 | UniProtKB | 20356844 | |
| 904 | dbPTM | 20356844 | |
| 904 | UniProtKB | 20356844 | |
| 1235 | N-GlycoSiteAtlas | 24741114 , 25247386 | |
| 1235 | PolarProtDb | 31844046 | |
| 1303 | N-GlycoSiteAtlas | 26256267 | |
| 1354 | N-GlycoSiteAtlas | 24741114 , 25247386 , 26256267 | |
| 1675 | PolarProtDb | 31844046 | |
| 1675 | N-GlycoSiteAtlas | 26256267 |
Family and domain data
| Database | Domain/Family name |
|---|---|
| InterPro | Gal_mutarotase_N |
| InterPro | Gal_mutarotase_sf_dom |
| InterPro | Glyco_hydro_31 |
| InterPro | Glyco_hydro_31_AS |
| InterPro | Glyco_hydro_31_CS |
| InterPro | Glyco_hydro_b |
| InterPro | Glycoside_hydrolase_SF |
| InterPro | P_trefoil_CS |
| InterPro | P_trefoil_dom |
| Pfam | Glyco_hydro_31 |
| Pfam | NtCtMGAM_N |
| Pfam | Trefoil |