Gene name
Sis
Experiment(s)
For this entry:
B5THE3_MOUSE (Sis)
| Species | Mus musculus |
|---|---|
| Localization | Apical plasma membrane |
| Reference |
Sato T,Mushiake S,Kato Y,Sato K,Sato M,Takeda N,Ozono K,Miki K,Kubo Y,Tsuji A,Harada R,Harada A (2007) The Rab8 GTPase regulates apical protein localization in intestinal cells., Nature, 448, 366-9. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Small intestine |
| Cell | Enterocytes |
| Notes | Apical localization dependent on Rab8 |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
| Start | End | Localisation |
|---|---|---|
| 1 | 10 | Cytoplasmic |
| 11 | 31 | Membrane |
| 32 | 1818 | Extracellular |
Family and domain data
| Database | Domain/Family name |
|---|---|
| InterPro | Gal_mutarotase_N |
| InterPro | Gal_mutarotase_sf_dom |
| InterPro | Glyco_hydro_31 |
| InterPro | Glyco_hydro_31_AS |
| InterPro | Glyco_hydro_31_CS |
| InterPro | Glyco_hydro_31_N_dom |
| InterPro | Glyco_hydro_b |
| InterPro | Glycoside_hydrolase_SF |
| InterPro | P_trefoil_CS |
| InterPro | P_trefoil_dom |
| Pfam | Gal_mutarotas_2 |
| Pfam | Glyco_hydro_31 |
| Pfam | NtCtMGAM_N |
| Pfam | Trefoil |