Gene name
SLC9A2 (NHE2)
Experiment(s)
For this entry:
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
| Start | End | Localisation |
|---|---|---|
| 1 | 34 | Signal peptide |
| 35 | 79 | Extracellular |
| 80 | 97 | Membrane |
| 98 | 106 | Cytoplasmic |
| 107 | 128 | Membrane |
| 129 | 138 | Extracellular |
| 139 | 157 | Membrane |
| 158 | 167 | Cytoplasmic |
| 168 | 192 | Membrane |
| 193 | 203 | Extracellular |
| 204 | 225 | Membrane |
| 226 | 235 | Cytoplasmic |
| 236 | 257 | Membrane |
| 258 | 273 | Extracellular |
| 274 | 299 | Membrane |
| 300 | 319 | Cytoplasmic |
| 320 | 341 | Membrane |
| 342 | 364 | Extracellular |
| 365 | 382 | Membrane |
| 383 | 391 | Cytoplasmic |
| 392 | 413 | Membrane |
| 414 | 429 | Extracellular |
| 430 | 449 | Membrane |
| 450 | 458 | Cytoplasmic |
| 459 | 479 | Membrane |
| 480 | 812 | Extracellular |
Phosphorylation
Glycosylation
![WURCS=2.0/2,2,1/[uxxxxh_2*NCC/3=O][uxxxxh]/1-2/a?|b?}-{a?|b?](data:image/png;base64,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)
Family and domain data
| Database | Domain/Family name |
|---|---|
| InterPro | Cation/H_exchanger |
| InterPro | Cation/H_exchanger_CPA1 |
| InterPro | Na/H_exchanger_2 |
| InterPro | NaH_exchanger |
| InterPro | NHE_CaM-bd |
| Pfam | Na_H_Exchanger |
| Pfam | NEXCaM_BD |
Interactions
| With (links to EBI) | #Exp | PubMed links |
|---|---|---|
| CFTR_HUMAN | 2 | 16203867 |
Protein can be found in apical membrane,
Protein can be found in basal membrane,
Protein can be found both membranes,
Localisation is unknown.