Gene name
SLC9A2 (NHE2)
Experiment(s)
For this entry:
SL9A2_RAT (SLC9A2)
| Species | Rattus norvegicus |
|---|---|
| Localization | Apical plasma membrane |
| Reference |
Nejsum LN,Praetorius J,Nielsen S (2005) NKCC1 and NHE1 are abundantly expressed in the basolateral plasma membrane of secretory coil cells in rat, mouse, and human sweat glands., Am J Physiol Cell Physiol, 289, C333-40. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Kidney |
| Cell | Proximal tubules |
| Notes |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
| Start | End | Localisation |
|---|---|---|
| 1 | 35 | Signal peptide |
| 36 | 80 | Extracellular |
| 81 | 99 | Membrane |
| 100 | 107 | Cytoplasmic |
| 108 | 129 | Membrane |
| 130 | 139 | Extracellular |
| 140 | 158 | Membrane |
| 159 | 168 | Cytoplasmic |
| 169 | 193 | Membrane |
| 194 | 204 | Extracellular |
| 205 | 226 | Membrane |
| 227 | 236 | Cytoplasmic |
| 237 | 258 | Membrane |
| 259 | 272 | Extracellular |
| 273 | 300 | Membrane |
| 301 | 314 | Cytoplasmic |
| 315 | 342 | Membrane |
| 343 | 365 | Extracellular |
| 366 | 384 | Membrane |
| 385 | 392 | Cytoplasmic |
| 393 | 414 | Membrane |
| 415 | 430 | Extracellular |
| 431 | 450 | Membrane |
| 451 | 459 | Cytoplasmic |
| 460 | 481 | Membrane |
| 482 | 813 | Extracellular |
Phosphorylation
Family and domain data
| Database | Domain/Family name |
|---|---|
| InterPro | Cation/H_exchanger |
| InterPro | Cation/H_exchanger_CPA1 |
| InterPro | Na/H_exchanger_2 |
| InterPro | NaH_exchanger |
| InterPro | NHE_CaM-bd |
| Pfam | Na_H_Exchanger |
| Pfam | NEXCaM_BD |